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NMDA Receptor 2A (AA 1064-1092), (Middle Region) antibody

Details for Product No. ABIN953720, Supplier: Log in to see
AA 1064-1092, Middle Region
Human, Mouse (Murine)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Immunogen KLH conjugated synthetic peptide between 1064-1092 amino acids from the Central region of Human NMDA Receptor 2A Genename: GRIN2A
Isotype Ig
Specificity This antibody recognizes Human and Mouse NMDA Receptor 2A (Center).
Purification Protein A column, followed by peptide affinity purification
Background N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Synonyms: GRIN2A, Glutamate [NMDA] Receptor subunit epsilon-1, NMDAR2A, NR2A
Molecular Weight 165283 Da
Gene ID 2903
NCBI Accession NP_000824
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-NMDA Receptor 2A (AA 1064-1092), (Middle Region) antibody (ABIN953720) Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tis...
Western Blotting (WB) image for anti-NMDA Receptor 2A (AA 1064-1092), (Middle Region) antibody (ABIN953720) Western blot analysis of NMDA Receptor 2A Antibody (Center) in mouse heart tissue lys...
Background publications King, Eugenin, Hazleton, Morgello, Berman: "Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis." in: The American journal of pathology, Vol. 176, Issue 6, pp. 2819-30, 2010 (PubMed).

Endele, Rosenberger, Geider, Popp, Tamer, Stefanova, Milh, Kortüm, Fritsch, Pientka, Hellenbroich, Kalscheuer, Kohlhase, Moog, Rappold, Rauch, Ropers, von Spiczak, Tönnies, Villeneuve, Villard, Zabel, Zenker, Laube, Reis, Wieczorek, Van Maldergem, Kutsche: "Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes." in: Nature genetics, Vol. 42, Issue 11, pp. 1021-6, 2010 (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Saus, Brunet, Armengol, Alonso, Crespo, Fernández-Aranda, Guitart, Martín-Santos, Menchón, Navinés, Soria, Torrens, Urretavizcaya, Vallès, Gratacòs, Estivill: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Pinheiro, Bulik, Thornton, Sullivan, Root, Bloss, Berrettini, Schork, Kaye, Bergen, Magistretti, Brandt, Crawford, Crow, Fichter, Goldman, Halmi, Johnson, Kaplan, Keel, Klump, La Via, Mitchell, Strober, Rotondo, Treasure, Woodside: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).