Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme (PPP3CC) (AA 17-45), (N-Term) antibody

Details for Product No. ABIN954277
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Synonyms ppp3cc, sb:cb767, si:dkey-21k4.5, calna3, cna3, pp2bgamma, Calnc, CALNA3, CNA3, PP2Bgamma
AA 17-45, N-Term
(21), (15), (6), (4), (2), (1), (1), (1), (1), (1), (1)
(41), (3), (3)
(39), (2)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(40), (22), (21), (7), (3), (3)
Pubmed 3 references available
Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
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Immunogen KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of Human PPP3CC
Isotype Ig
Specificity This antibody recognizes Human PPP3CC / CALNA3 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PPP3CC / CALNA3 (PPP3CC Antibody Abstract)
Background Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1, MIM 114105), calcineurin A-beta (CALNA2, MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95 % amino acid identity).Synonyms: CAM-PRP catalytic subunit, CNA3, Calcineurin testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, protein phosphatase 2B catalytic subunit gamma
Molecular Weight 58129 Da
Gene ID 5533
NCBI Accession NP_005596
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications He, Hu, Li et al.: "Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults." in: European journal of applied physiology, Vol. 110, Issue 4, pp. 761-7, 2010 (PubMed).

Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Liu, Guo, Zhang et al.: "Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity." in: Obesity (Silver Spring, Md.), Vol. 18, Issue 12, pp. 2339-46, 2010 (PubMed).

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Catalog No. ABIN954277
357.50 $
Plus shipping costs $45.00
0.4 mL
357.50 $

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