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PRKAA2 antibody (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit) (AA 148-177)

Details for Product anti-PRKAA2 Antibody No. ABIN954298, Supplier: Login to see
Antigen
  • ampk
  • ampk2
  • prkaa
  • prkaa1
  • PRKAA2
  • AMPK
  • AMPK2
  • AMPKa2
  • PRKAA
  • Ampk
  • Ampka2
  • 2310008I11Rik
  • A830082D05
  • AMPKalpha2
  • AMPKA2
Alternatives
anti-Human PRKAA2 antibody for Western Blotting
Epitope
AA 148-177, Middle Region, Thr172
46
18
16
15
15
14
13
13
13
6
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
220
84
66
6
4
4
2
1
1
1
1
Host
Rabbit
186
25
17
1
Clonality
Polyclonal
Conjugate
This PRKAA2 antibody is un-conjugated
11
11
11
8
8
8
3
3
3
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
171
103
61
33
22
22
16
13
5
3
2
1
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 148-177 amino acids from the Central region of human PRKAA2 (Thr172)
Isotype Ig
Specificity This antibody reacts to PRKAA2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name PRKAA2 (PRKAA2 Antibody Abstract)
Background The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.Synonyms: 5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK alpha-2 chain, AMPK2
Molecular Weight 62320 Da
Gene ID 5563
NCBI Accession NP_006243
Pathways AMPK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-PRKAA2 antibody (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit) (AA 148-177) (ABIN954298) PRKAA2 (Thr172) Antibody (Center) flow cytometric analysis of K562 cells (right histo...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-PRKAA2 antibody (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit) (AA 148-177) (ABIN954298) PRKAA2 (Thr172) antibody (Center) immunohistochemistry analysis in formalin fixed and...
Western Blotting (WB) image for anti-PRKAA2 antibody (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit) (AA 148-177) (ABIN954298) PRKAA2 (Thr172) Antibody western blot analysis in K562 cell line lysates (35µg/lane)....
Background publications Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Bungard, Fuerth, Zeng et al.: "Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation." in: Science (New York, N.Y.), Vol. 329, Issue 5996, pp. 1201-5, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).