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ATM antibody

ATM Reactivity: Human WB, ELISA Host: Mouse Monoclonal 5C5 unconjugated
Catalog No. ABIN965618
  • Target See all ATM Antibodies
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Reactivity
    • 154
    • 66
    • 31
    • 1
    • 1
    • 1
    Human
    Host
    • 125
    • 23
    • 5
    • 2
    Mouse
    Clonality
    • 121
    • 34
    Monoclonal
    Conjugate
    • 79
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    This ATM antibody is un-conjugated
    Application
    • 69
    • 51
    • 39
    • 35
    • 28
    • 24
    • 24
    • 21
    • 20
    • 12
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Purification
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human ATM expressed in E. Coli.
    Clone
    5C5
    Isotype
    IgG1
    Top Product
    Discover our top product ATM Primary Antibody
  • Application Notes
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Goodarzi, Noon, Deckbar, Ziv, Shiloh, Löbrich, Jeggo: "ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin." in: Molecular cell, Vol. 31, Issue 2, pp. 167-77, (2008) (PubMed).

    ORegan, Kiely, OGara: "Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes?" in: Gene, Vol. 83, Issue 2, pp. 243-9, (1990) (PubMed).

    Renkawitz, Beug, Graf, Matthias, Grez, Schütz: "Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells." in: Cell, Vol. 31, Issue 1, pp. 167-76, (1983) (PubMed).

  • Target
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Alternative Name
    ATM (ATM Products)
    Background
    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
    Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
    Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, ATM
    Molecular Weight
    351kDa
    Gene ID
    472
    Pathways
    p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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