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Details for Product No. ABIN965618

Ataxia Telangiectasia Mutated (ATM) antibody

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Antigen
Synonyms AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik, ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 4 references available
Catalog no. ABIN965618
Quantity 0.1 mL
Price
467.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days

Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen Purified recombinant fragment of human ATM expressed in E. Coli.
Clone 5C5
Isotype IgG1
Purification Ascitic fluid

Target Details

Application Details Handling References Alternatives back to top
Alternative Name ATM
Background The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, ATM
Molecular Weight 351kDa
Gene ID 472
Research Area Cancer, DNA/RNA

Application Details

Target Details Handling References Alternatives back to top
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Preservative Sodium azide
Storage 4 °C

References

Target Details Application Details Handling Alternatives back to top
Product cited in: ORegan, Kiely, OGara: "Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes?" in: Gene, Vol. 83, Issue 2, pp. 243-9, 1990 (PubMed).

Renkawitz, Beug, Graf et al.: "Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells." in: Cell, Vol. 31, Issue 1, pp. 167-76, 1983 (PubMed).

Goodarzi, Noon, Deckbar et al.: "ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin." in: Molecular cell, Vol. 31, Issue 2, pp. 167-77, 2008 (PubMed).

Smirnov, Cheung: "ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs." in: American journal of human genetics, Vol. 83, Issue 2, pp. 243-53, 2008 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Ataxia Telangiectasia Mutated (ATM)", type "Antibodies"
Hosts (148), (52), (18), (4), (3)
Reactivities (214), (72), (44), (5), (4), (1), (1)
Applications (135), (70), (51), (42), (40), (39), (33), (14), (10), (4), (3), (2), (2)
Conjugates (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Epitopes (46), (15), (12), (12), (4), (4), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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