Ataxia Telangiectasia Mutated (ATM) antibody

Details for Product No. ABIN965618
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Antigen
Synonyms ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik
Reactivity
Human
(231), (57), (26), (3), (2), (1), (1)
Host
Mouse
(167), (41), (16), (7), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(137), (54), (52), (46), (43), (39), (30), (13), (12), (8), (5), (5), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN965618
481.25 $
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Immunogen Purified recombinant fragment of human ATM expressed in E. Coli.
Clone 5C5
Isotype IgG1
Purification Ascitic fluid
Alternative Name ATM
Background The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, ATM
Molecular Weight 351kDa
Gene ID 472
Research Area Cancer, DNA/RNA
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Smirnov, Cheung: "ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs." in: American journal of human genetics, Vol. 83, Issue 2, pp. 243-53, 2008 (PubMed).

Goodarzi, Noon, Deckbar et al.: "ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin." in: Molecular cell, Vol. 31, Issue 2, pp. 167-77, 2008 (PubMed).

Renkawitz, Beug, Graf et al.: "Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells." in: Cell, Vol. 31, Issue 1, pp. 167-76, 1983 (PubMed).

ORegan, Kiely, OGara: "Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes?" in: Gene, Vol. 83, Issue 2, pp. 243-9, 1990 (PubMed).

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