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FANCD2 antibody (Isoform B)

FANCD2 Reactivity: Human, Mouse IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN966127
  • Target See all FANCD2 Antibodies
    FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))
    Binding Specificity
    • 16
    • 15
    • 15
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Isoform B
    Reactivity
    • 102
    • 25
    • 22
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 101
    • 2
    Rabbit
    Clonality
    • 91
    • 12
    Polyclonal
    Conjugate
    • 35
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This FANCD2 antibody is un-conjugated
    Application
    • 29
    • 27
    • 27
    • 24
    • 16
    • 14
    • 12
    • 9
    • 8
    • 7
    • 6
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Immunogen
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human FANCD2 (Fanconi anemia complementation group D2 isoform b)
    Top Product
    Discover our top product FANCD2 Primary Antibody
  • Restrictions
    For Research Use only
  • Storage
    4 °C
  • Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, (2009) (PubMed).

    Singh, Bakker, Agarwal, Jansen, Grassman, Godthelp, Ali, Du, Rooimans, Fan, Wahengbam, Steltenpool, Andreassen, Williams, Joenje, de Winter, Meetei: "Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M." in: Blood, Vol. 114, Issue 1, pp. 174-80, (2009) (PubMed).

    Kuhnert, Kachnic, Li, Purschke, Gheorghiu, Lee, Held, Willers: "FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions." in: International journal of radiation biology, Vol. 85, Issue 6, pp. 523-31, (2009) (PubMed).

    Chan, Palmai-Pallag, Ying, Hickson: "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis." in: Nature cell biology, Vol. 11, Issue 6, pp. 753-60, (2009) (PubMed).

  • Target
    FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))
    Alternative Name
    FANCD2 (FANCD2 Products)
    Synonyms
    FANCD2 antibody, CG17269 antibody, CG31192 antibody, CG31194 antibody, Dmel\\CG17269 antibody, dmFANCD2 antibody, xfancd2 antibody, FA-D2 antibody, FA4 antibody, FACD antibody, FAD antibody, FAD2 antibody, FANCD antibody, 2410150O07Rik antibody, AU015151 antibody, BB137857 antibody, Fanconi anemia complementation group D2 antibody, CG17269 gene product from transcript CG17269-RA antibody, Fanconi anemia group D2 protein antibody, Fanconi anemia, complementation group D2 antibody, Fanconi anemia complementation group D2 L homeolog antibody, FANCD2 antibody, Fancd2 antibody, LOC100455970 antibody, fancd2 antibody, fancd2.L antibody
    Background
    The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homologydirected DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.
    Pathways
    DNA Damage Repair
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