FANCD2 Products
(Fanconi Anemia, Complementation Group D2 (FANCD2))
Categories
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured FANCD2 Categories
FANCD2 Antibodies
High quality antibodies with extensive validation data.
FANCD2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended FANCD2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IHC (p), IP
Validations
- (5)
- (4)
Cat. No.
ABIN540721
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IF, IP, ICC
Validations
- (6)
Cat. No.
ABIN363390
Quantity
0.05 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (4)
Cat. No.
ABIN3022849
Quantity
100 μL
Datasheet
Datasheet
Recommended FANCD2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380171
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended FANCD2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092566
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136034
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7424686
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FANCD2 products
: "Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility." in: PLoS genetics, Vol. 14, Issue 12, pp. e1007821, (2019) (PubMed).: "Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia." in: Nature communications, Vol. 9, Issue 1, pp. 3915, (2019) (PubMed).
: "Mammalian INO80 chromatin remodeler cooperates with FANCM to mediate DNA interstrand crosslink-induced checkpoint activation and repair." in: DNA repair, Vol. 74, pp. 38-50, (2019) (PubMed).
: "Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability." in: Nucleic acids research, (2019) (PubMed).
: "Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. ..." in: EMBO molecular medicine, (2019) (PubMed).
: "Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2." in: Cell reports, Vol. 27, Issue 6, pp. 1794-1808.e5, (2019) (PubMed).
: "Dicer prevents genome instability in response to replication stress." in: Oncotarget, Vol. 10, Issue 43, pp. 4407-4423, (2019) (PubMed).
: "FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2." in: Nature communications, Vol. 8, Issue 1, pp. 1073, (2018) (PubMed).
: "Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity." in: BMC research notes, Vol. 11, Issue 1, pp. 138, (2018) (PubMed).
: "Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2." in: Molecular cell, Vol. 71, Issue 1, pp. 25-41.e6, (2018) (PubMed).
Synonyms and alternative names related to FANCD2
Fanconi anemia complementation group D2 (FANCD2), CG17269 gene product from transcript CG17269-RA (Fancd2), Fanconi anemia group D2 protein (LOC100455970), Fanconi anemia complementation group D2 (fancd2), Fanconi anemia, complementation group D2 (fancd2), Fanconi anemia complementation group D2 L homeolog (fancd2.L), Fanconi anemia, complementation group D2 (FANCD2), Fanconi anemia, complementation group D2 (Fancd2), 2410150O07Rik, AU015151, BB137857, CG17269, CG31192, CG31194, Dmel\\CG17269, dmFANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD, FANCD2, xfancd2Protein level used designations for FANCD2
- Fanconi anemia, complementation group D2
- CG17269-PA
- Fancd2-PA
- Fanconi anemia group D2 protein-like
- fanconi anemia protein FANCD2
- Fanconi anemia complementation group D2
- Fanconi anemia group D2 protein
- Fanconi anemia group D2 protein homolog
- Fanconi anemia D2 protein
Did you look for something else?
- FANCC
- FANCB
- FANCA
- FAN1
- Family with Sequence Similarity 92, Member A1
- Family with Sequence Similarity 69, Member C
- Family with Sequence Similarity 58, Member B
- Family with Sequence Similarity 50, Member A
- Family with Sequence Similarity 46, Member B
- Family with Sequence Similarity 220, Member A
- Family with Sequence Similarity 212, Member A
- Family with Sequence Similarity 21, Member B
- Family with Sequence Similarity 102, Member B
- Family with Sequence Similarity 102, Member A
- FAM9C
- FAM9B
- FAM9A
- FAM98C
- FAM98B
- FAM98A
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