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Fanconi Anemia, Complementation Group D2 (FANCD2) (Isoform B), (ubiquitinated) antibody

Details for Product No. ABIN966128, Supplier: Log in to see
Antigen
  • FANCD2
  • CG17269
  • CG31192
  • CG31194
  • Dmel\\CG17269
  • dmFANCD2
  • xfancd2
  • FA-D2
  • FA4
  • FACD
  • FAD
  • FAD2
  • FANCD
  • 2410150O07Rik
  • AU015151
  • BB137857
Epitope
Isoform B, ubiquitinated
17
13
10
5
4
4
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
99
47
39
3
2
Host
Rabbit
91
13
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
67
38
28
24
21
13
9
2
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human FANCD2 (Fanconi anemia complementation group D2 isoform b)
Characteristics Note: At K561 amino acid residue with the ubiquitin c-terminal 7-mer peptide bound: CLRLRGG
Alternative Name FANCD2 (FANCD2 Antibody Abstract)
Background The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homologydirected DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.
Pathways
Restrictions For Research Use only
Product cited in: Kweekel, Antonini, Nortier et al.: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, 2009 (PubMed).

Kuhnert, Kachnic, Li et al.: "FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions." in: International journal of radiation biology, Vol. 85, Issue 6, pp. 523-31, 2009 (PubMed).

Chan, Palmai-Pallag, Ying et al.: "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis." in: Nature cell biology, Vol. 11, Issue 6, pp. 753-60, 2009 (PubMed).

Singh, Bakker, Agarwal et al.: "Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M." in: Blood, Vol. 114, Issue 1, pp. 174-80, 2009 (PubMed).

Background publications Garcia-Higuera, Taniguchi, Ganesan et al.: "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway." in: Molecular cell, Vol. 7, Issue 2, pp. 249-62, 2001 (PubMed).

Timmers, Taniguchi, Hejna et al.: "Positional cloning of a novel Fanconi anemia gene, FANCD2." in: Molecular cell, Vol. 7, Issue 2, pp. 241-8, 2001 (PubMed).