Forkhead Box O1 (FOXO1) antibody

Details for Product No. ABIN966149
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Antigen
Synonyms FOXO1, FOXO1A, fkh1, fkhr, foxo1a, xFoxO1, FKH1, FKHR, AI876417, Afxh, Fkhr1, Foxo1a, Fkhr, FoxO1A, FoxO1a.1, foxo1, zgc:153388
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(309), (169), (146), (41), (41), (41), (25), (2), (1), (1), (1)
Host
Rabbit
(255), (47), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Immunohistochemistry (IHC)
(243), (118), (85), (75), (61), (50), (25), (23), (5), (4), (4), (3), (2)
Pubmed 4 references available
Quantity 100 μg
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Catalog No. ABIN966149
398.75 $
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human FKHR around the phosphorylation site of serine 319.
Specificity FKHR (Ab-319) antibody detects endogenous levels of total FKHR protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name FKHR
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Zhao, Gan, Pan et al.: "Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 839-49, 2004 (PubMed).

Rena, Woods, Prescott et al.: "Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion." in: The EMBO journal, Vol. 21, Issue 9, pp. 2263-71, 2002 (PubMed).

Rena, Prescott, Guo et al.: "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting." in: The Biochemical journal, Vol. 354, Issue Pt 3, pp. 605-12, 2001 (PubMed).

Guo, Rena, Cichy et al.: "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 17184-92, 1999 (PubMed).

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