Forkhead Box O1 (FOXO1) antibody

Details for Product No. ABIN966149
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Antigen
Synonyms FKH1, FKHR, FOXO1A, Afxh, Fkhr1, Foxo1a, AI876417, Fkhr, foxo1, FoxO1a.1, zgc:153388, FoxO1A, FOXO1, fkh1, fkhr, foxo1a, xFoxO1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(300), (182), (160), (77), (77), (77), (62), (2), (1), (1)
Host
Rabbit
(246), (51), (8), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Immunohistochemistry (IHC)
(230), (98), (94), (77), (60), (48), (38), (4), (3), (3), (3), (2), (1)
Pubmed 4 references available
Catalog no. ABIN966149
Quantity 100 µg
Price
385.00 $   Plus shipping costs $45.00
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human FKHR around the phosphorylation site of serine 319.
Specificity FKHR (Ab-319) antibody detects endogenous levels of total FKHR protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name FKHR
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Guo, Rena, Cichy et al.: "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 17184-92, 1999 (PubMed).

Rena, Prescott, Guo et al.: "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting." in: The Biochemical journal, Vol. 354, Issue Pt 3, pp. 605-12, 2001 (PubMed).

Rena, Woods, Prescott et al.: "Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion." in: The EMBO journal, Vol. 21, Issue 9, pp. 2263-71, 2002 (PubMed).

Zhao, Gan, Pan et al.: "Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 839-49, 2004 (PubMed).

Hosts (246), (51), (8), (1)
Reactivities (300), (182), (160), (77), (77), (77), (62), (2), (1), (1)
Applications (230), (98), (94), (77), (60), (48), (38), (4), (3), (3), (3), (2), (1)
Conjugates (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (41), (38), (23), (14), (13), (12), (11), (9), (8), (8), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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