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PPARG antibody (Peroxisome Proliferator-Activated Receptor gamma) (N-Term)

Details for Product anti-PPARG Antibody No. ABIN966886, Supplier: Login to see New
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Antigen
Synonyms PPAR gamma, PPARg2, PPARG, Nr1c3, PPAR-gamma, PPAR-gamma2, PPARgamma, PPARgamma2, NR1C3, CIMT1, GLM1, PPARG1, PPARG2, xPPAR-gamma, PPAR-GAMMA, PPARGAMMA
Alternatives
Epitope
N-Term
(49), (23), (17), (14), (13), (13), (13), (11), (10), (9), (7), (6), (6), (6), (6), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(256), (110), (90), (17), (15), (9), (8), (5), (5), (4), (4), (4), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(251), (28), (6), (6)
Clonality
Polyclonal
Conjugate
This PPARG antibody is un-conjugated
(20), (15), (8), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(216), (125), (46), (46), (35), (20), (17), (16), (15), (10), (6), (6), (2), (2), (1), (1)
Pubmed 3 references available
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Quantity 100 μg
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human PPAR-G, different from the rat and mouse sequences by two amino acids.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Peroxisome proliferator-activated receptor gamma ( PPARG) detection. Tested with WB in Human.
Background The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPAR gamma, PPAR alpha, and PPAR delta, encoded by different genes. PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements (PPREs) within promoters. PPAR gamma is a transcription factor that has a pivotal role in adipocyte differentiation and expression of adipocyte-specific genes. The PPAR gamma1 and gamma2 isoforms result from alternative splicing and have ligand-dependent and -independent activation domains. PPAR gamma is a member of a family of nuclear receptors/ligand-dependent transcription factors, which bind to hormone response elements on target gene promoters. Ameshima et al. (2003) found that PPAR gamma is abundantly expressed in normal lung tissues, especially in endothelial cells, but that its expression is reduced or absent in the angiogenic plexiform lesions of pulmonary hypertensive lungs and in the vascular lesions of a rat model of severe pulmonary hypertension. And they conclude that fluid shear stress decreases the expression of PPARgamma in endothelial cells and that loss of PPARgamma expression characterizes an abnormal, proliferating, apoptosis-resistant endothelial cell phenotype.
Pathways MAPK Signaling, Nuclear Receptor Transcription Pathway
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Ameshima, Golpon, Cool et al.: "Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth." in: Circulation research, Vol. 92, Issue 10, pp. 1162-9, 2003 (PubMed).

Berger, Moller: "The mechanisms of action of PPARs." in: Annual review of medicine, Vol. 53, pp. 409-35, 2002 (PubMed).

Deeb, Fajas, Nemoto et al.: "A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity." in: Nature genetics, Vol. 20, Issue 3, pp. 284-7, 1998 (PubMed).

Catalog No. ABIN966886
$330.00
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