Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Middle Region) antibody

Details for Product No. ABIN967209
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Antigen
Synonyms trk, trka, TRKA, MTC, TRK, TRK1, Trk-A, p140-TrkA, C80751, Tkr, TrkA, Trk, CTRKA, trkA, CAPM1, CFTD, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, hscp30
Epitope
Middle Region
(37), (23), (21), (18), (18), (16), (16), (16), (12), (12), (12), (12), (12), (12), (12), (12), (10), (9), (8), (8), (6), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(311), (179), (171), (29), (29), (12), (12)
Host
Rabbit
(298), (29), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (10), (10), (7), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(200), (148), (68), (60), (47), (46), (36), (28), (21), (10), (3), (1)
Pubmed 3 references available
Quantity 100 μg
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Catalog No. ABIN967209
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Immunogen A synthetic peptide corresponding to a sequence in the middle region of human NTRK1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor ( NTRK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Alternative Name High affinity nerve growth factor receptor (NTRK1)
Background Trk A (Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor (NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF4 (Neurotrophin-4) and BDNF, and NTF3 (Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA (NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform (s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes. Indo et al. (1996) concluded that defects in TRKA cause CIPA (Congenital insensitivity to pain with anhidrosis ) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect (s) of the nervous system.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Indo, Tsuruta, Hayashida et al.: "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis." in: Nature genetics, Vol. 13, Issue 4, pp. 485-8, 1996 (PubMed).

Bonini, Lambiase, Bonini et al.: "Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10955-60, 1996 (PubMed).

Lambiase, Merlo, Mollinari et al.: "Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16795-800, 2005 (PubMed).

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