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Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibody

Details for Product No. ABIN967651
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Antigen
Synonyms TNFRSF4, ACT35, CD134, Ly-70, Ox40, TXGP1L, Txgp1, OX40
Reactivity
Mouse (Murine)
(64), (44), (41), (17), (17), (5)
Host
Rat
(48), (43), (31), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(20), (17), (10), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(88), (36), (19), (17), (14), (11), (8), (7), (3), (1), (1)
Pubmed 8 references available
Quantity 0.5 mg
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Catalog No. ABIN967651
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Immunogen Recombinant Mouse OX-40 3/4 CD4 Chimeric Protein
Clone OX-86
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CD134
Background The OX-86 mAb reacts with the OX-40 antigen (CD134), also known as OX-40 receptor, which is a 50-kDa type-I membrane glycoprotein that belongs to the NGFR/TNFR superfamily. Mouse CD134 is expressed on activated CD4+ and CD8+ T lymphocytes and has been shown to be the sole receptor for the OX-40 Ligand (OX-40L). In the brains of mice with actively induced experimental allergic encephalomyelitis, the expression of CD134 on CD4+ T lymphocytes correlates with disease progression. The OX-40/OX-40L system supplies a costimulatory signal for T-cell proliferation and B-cell proliferation and differentiation. In addition, OX-40 antigen provides a costimulatory signal that induces T cells to proliferate in a CD28-independent manner. In the intact animal, CD134 does not appear to be essential for many T-cell responses, but it seems to play a major role in the pathogenesis of some autoimmune diseases. The OX-86 mAb stains both CD4+ and CD8+ activated T cells, and this expression pattern has been confirmed using OX-40L-Ig fusion protein. CD134 was also detected, using OX-86 mAb, on B cells after stimulation with anti-IgM plus anti-CD40 mAb HM40-3. OX-86 mAb does not block binding of OX-40L to OX-40, and it stimulates T-cell proliferation mildly.
Synonyms: OX-40 Antigen
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Stüber, Neurath, Calderhead et al.: "Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells." in: Immunity, Vol. 2, Issue 5, pp. 507-21, 1995 (PubMed).

Baum, Gayle, Ramsdell et al.: "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34." in: The EMBO journal, Vol. 13, Issue 17, pp. 3992-4001, 1994 (PubMed).

al-Shamkhani, Birkeland, Puklavec et al.: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." in: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, 1996 (PubMed).

Weinberg, Vella, Croft: "OX-40: life beyond the effector T cell stage." in: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, 1999 (PubMed).

Higgins, McDonald, Whittle et al.: "Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 1, pp. 486-93, 1999 (PubMed).

Weinberg, Wegmann, Funatake et al.: "Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1818-26, 1999 (PubMed).

Akiba, Oshima, Takeda et al.: "CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7058-66, 1999 (PubMed).

Pippig, Peña-Rossi, Long et al.: "Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6520-9, 2000 (PubMed).

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