TNFRSF4 antibody (AA 59-205)

Catalog No. ABIN6940817

Product Details anti-TNFRSF4 Antibody

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Binding Specificity: AA 59-205

Reactivity: Human, Chimpanzee

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF4 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Coating (Coat), Immunostaining (ISt), Staining Methods (StM)

Specificity: ThisMAb recognizes a protein of 43 kDa, identified as OX40, which is also known as CD134.OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells.OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment of human OX40 (CD134) protein (around aa 59-205) (exact sequence is proprietary)

Clone: OX40-3108

Isotype: IgG2c kappa

Application Details

Application Notes:

Positive Control: MOLT-4 cells. Human peripheral blood leukocytes (hPBL). Human tonsil tissue (IHC).

Known Application: ELISA (For coating, order antibody without BSA),Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TNFRSF4

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Alternative Name: TNFRSF4 (TNFRSF4 Products)

Synonyms: TNFRSF4 antibody, ACT35 antibody, CD134 antibody, Ly-70 antibody, Ox40 antibody, TXGP1L antibody, Txgp1 antibody, OX40 antibody, TNF receptor superfamily member 4 antibody, tumor necrosis factor receptor superfamily, member 4 antibody, TNFRSF4 antibody, Tnfrsf4 antibody

Molecular Weight: 43kDa

Gene ID: 7293

UniProt: P43489

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints