Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody

Details for Product No. ABIN967767
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Antigen
Synonyms SHP, SHP-1, Shp1, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1L, SHP1, Hcph, Ptp1C, hcp, me, motheaten, Ptph6, Shp-1, DRPLA
Epitope
AA 492-597
(35), (23), (17), (12), (12), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(187), (93), (92), (52), (36), (24), (12), (12), (1)
Host
Mouse
(144), (31), (13)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
(126), (63), (50), (45), (34), (26), (11), (11), (7), (7), (5), (3), (2)
Pubmed 5 references available
Quantity 150 μg
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Catalog No. ABIN967767
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Immunogen Human PTP1C
Clone AA6
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PTP1C
Background PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells. It contains two N-terminal SH2 domains and a C-terminal phosphatase domain. While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates. This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors. Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells. Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway.
Molecular Weight 68 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody Immunofluorescent staining on HL60 cells.
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody (2) Western blot analysis of PTP1C on Jurkat cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-PTP1C.
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody (3) anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody (Image 3)
Product cited in: Kenner, Anyanwu, Olefsky et al.: "Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling." in: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19810-6, 1996 (PubMed).

Liu, Hill, Chernoff: "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)." in: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31290-5, 1997 (PubMed).

Lund-Johansen, Davis, Bishop et al.: "Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions." in: Cytometry, Vol. 39, Issue 4, pp. 250-9, 2000 (PubMed).

Keilhack, Müller, Böhmer et al.: "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1." in: The Journal of cell biology, Vol. 152, Issue 2, pp. 325-34, 2001 (PubMed).

Duchene, Schanstra, Pecher et al.: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, 2002 (PubMed).

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