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Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (AA 1-178) antibody

Antigen

Signal Transducer and Activator of Transcription 2, 113kDa (STAT2)
Synonyms P113, ISGF-3, STAT113, MGC59816, AW496480, 1600010G07Rik, STAT2, stat2
Binding Site
Alternatives

AA 1-178
Clonality Monoclonal (22)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunoprecipitation (IP)
5 references available
Catalog no. ABIN967806
Quantity
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anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (AA 1-178) antibody

Additional Information
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Alternative name Stat2
Immunogen Human Stat2
Format Liquid
Isotype IgG2a
Clone 22
Description The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. These three polypeptides contain both SH2 and SH3 domains and have also been described as members of the ISGF3 (interferon-stimulated gene factor 3) complex. With the discovery of additional members of the Stat family (Stats3 & 4), the nomenclature has been revised to indicate the Stat family members in the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. In response to IFN-alpha treatment, Stat1alpha, Stat1beta, and Stat2 become tyrosine-phosphorylated and migrate to the nucleus where they join a 48 kDa DNA binding protein and subsequently direct the transcription at IFN-alpha responsive elements. The genes encoding Stat2 and Stat1 are closely related. An extended acidic C-terminal region exclusive to Stat2 implicates a potential role in gene activation. Stat2 phosphorylation can occur independently of Stat1alpha, but phosphorylated Stat2 does appear to be dependent on its interaction with Stat1alpha for efficient nuclear localization and/or stability.
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Molecular Weight 113 kDa
Comments

Related Products: ABIN968586, ABIN967389

Application Details
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Concentration 250 µg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative 0.09% Sodium azide.
Storage Store undiluted at -20° C.
Research Area Signaling, Receptors, Inflammation
Restrictions For Research Use only

Publications
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Product Fu, Schindler, Improta et al.: "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7840-3, 1992 (PubMed).

Ruff-Jamison, Chen, Cohen: "Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei." in: Science (New York, N.Y.), Vol. 261, Issue 5129, pp. 1733-6, 1993 (PubMed).

Duff, Quinlan, Paxton et al.: "Pervanadate mimics IFNgamma-mediated induction of ICAM-1 expression via activation of STAT proteins." in: The Journal of investigative dermatology, Vol. 108, Issue 3, pp. 295-301, 1997 (PubMed).

Russell-Harde, Wagner, Rani et al.: "Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells." in: The Journal of biological chemistry, Vol. 275, Issue 31, pp. 23981-5, 2000 (PubMed).

Blesofsky, Mowen, Arduini et al.: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, 2001 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Signal Transducer and Activator of Transcription 2, 113kDa (STAT2)", type "Antibodies"
Hosts Rabbit (88), Mouse (6)
Reactivities Human (84), Mouse (Murine) (43), Rat (Rattus) (40), Dog (Canine) (6), Horse (Equine) (6), Chimpanzee (1), Cow (Bovine) (1), Macaque (1), Pig (Porcine) (1), Vervet monkey (Chlorocebus pygerythrus) (1)
Applications Western Blotting (WB) (63), ELISA (29), Immunohistochemistry (IHC) (22), Immunofluorescence (IF) (21), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (14), Immunoprecipitation (IP) (7), Flow Cytometry (FACS) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Fluorescence Microscopy (FM) (2), Immunocytochemistry (ICC) (2), Cellular Assay (CA) (1), Dot Blot (Dot) (1), Enzyme Immunoassay (EIA) (1), Immunoassay (IA) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1), Immunostaining (ISt) (1)
Conjugates Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Biotin (1), CF (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes C-Term (7), pTyr690 (7), pTyr689 (4), Tyr690 (3), pTyr631,Internal Region (3), AA 671-806 (2), AA 672-925 (1), AA 679-851 (1), AA 830-849 (1), AA 832-851 (1), N-Term (1), N-Term,pTyr690 (1), Phosphospecific (1), pSer727 (1), pTyr690,Internal Region (1), phospho (1)