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STAT2 antibody (Signal Transducer and Activator of Transcription 2, 113kDa) (AA 1-178)

Details for Product anti-STAT2 Antibody No. ABIN967806, Supplier: Login to see New
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Synonyms wu:fj84d07, p113, stat2, 1600010G07Rik, AW496480, ISGF-3, P113, STAT113
AA 1-178
(44), (43), (23), (17), (15), (15), (13), (13), (11), (9), (9), (5), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(222), (83), (59), (3), (3), (3), (3), (3), (3), (3), (3)
(236), (24), (1)
Clonality (Clone)
Monoclonal ()
This STAT2 antibody is un-conjugated
(10), (9), (8), (6), (6), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(209), (92), (92), (32), (24), (22), (7), (5), (4), (4), (4), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Human Stat2 aa. 1-178
Clone 22-Stat2
Isotype IgG2a
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Stat2 (STAT2 Antibody Abstract)
Background The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. These three polypeptides contain both SH2 and SH3 domains and have also been described as members of the ISGF3 (interferon-stimulated gene factor 3) complex. With the discovery of additional members of the Stat family (Stats3 & 4), the nomenclature has been revised to indicate the Stat family members in the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. In response to IFN-alpha treatment, Stat1alpha, Stat1beta, and Stat2 become tyrosine-phosphorylated and migrate to the nucleus where they join a 48 kDa DNA binding protein and subsequently direct the transcription at IFN-alpha responsive elements. The genes encoding Stat2 and Stat1 are closely related. An extended acidic C-terminal region exclusive to Stat2 implicates a potential role in gene activation. Stat2 phosphorylation can occur independently of Stat1alpha, but phosphorylated Stat2 does appear to be dependent on its interaction with Stat1alpha for efficient nuclear localization and/or stability.
Molecular Weight 113 kDa
Research Area Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling

Related Products: ABIN968586, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-STAT2 antibody (Signal Transducer and Activator of Transcription 2, 113kDa) (AA 1-178) (ABIN967806) Western blot analysis of Stat2 on a K-562 cell lysate (Human bone marrow myelogenous ...
Product cited in: Blesofsky, Mowen, Arduini et al.: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, 2001 (PubMed).

Russell-Harde, Wagner, Rani et al.: "Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells." in: The Journal of biological chemistry, Vol. 275, Issue 31, pp. 23981-5, 2000 (PubMed).

Duff, Quinlan, Paxton et al.: "Pervanadate mimics IFNgamma-mediated induction of ICAM-1 expression via activation of STAT proteins." in: The Journal of investigative dermatology, Vol. 108, Issue 3, pp. 295-301, 1997 (PubMed).

Ruff-Jamison, Chen, Cohen: "Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei." in: Science (New York, N.Y.), Vol. 261, Issue 5129, pp. 1733-6, 1993 (PubMed).

Fu, Schindler, Improta et al.: "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7840-3, 1992 (PubMed).

Catalog No. ABIN967806
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