STAT2 antibody

Catalog No. ABIN6940668

The Mouse Monoclonal anti-STAT2 antibody (Clone STAT2-2650) (ABIN6940668) specifically detects STAT2 in IHC. The antibody is reactive with Human samples.

Quick Overview for STAT2 antibody (ABIN6940668)

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAT2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: STAT2-2650

Product Details anti-STAT2 Antibody

Purpose: STAT2 Antibody

Specificity: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN- is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human STAT2 protein

Isotype: IgG1, kappa

Application Details

Application Notes:

Positive Control: Ramos and Jurkat cell lysates. HeLa cell extract. Human lung carcinoma tissue.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Alternative Name: STAT2

Background:

Homo sapiens interferon alpha induced transcriptional activator, interferon alpha induced transcriptional activator (ISGF3), P113, signal transducer and activator of transcription 2 113kD (STAT113), Signal transducer and activator of transcription 2 (STAT2)

Ramos and Jurkat cell lysates. HeLa cell extract. Human lung carcinoma tissue.

Molecular Weight: 113kDa

Gene ID: 6773, 530595

UniProt: P52630

Pathways: JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events