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Details for Product No. ABIN967850

Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 1-197) antibody

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P27, ISG12, FAM14D, ISG12A, KIP1, MEN4, CDKN4, MEN1B, P27KIP1, AA408329, AI843786, Kip1, p27, p27Kip1, 1500011J20Rik, 2610202L11Rik, Bridge-1, Cdki1b, cdkn1b, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18 ... show more
»Alternatives AA 1-197
»Alternatives Mouse (Murine)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 6 references available
Catalog no. ABIN967850
Quantity 50 µg
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Immunogen Mouse Kip1
Clone 65E
Isotype IgG1
Cross-Reactivity Human, Dog (Canine), Rat (Rattus), Chicken, Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name p27 Kip1
Background Kip1 is a cyclin-dependent kinase (cdk) inhibitor that was identified as a result of its role in TGFbeta-induced G1 phase arrest and cell-cell contact. In vitro , p27 [Kip1] binds tightly to Cyclin D-Cdk4, Cyclin E-Cdk2, and Cyclin A-Cdk2 complexes and inhibits their activity. In normal cells, Kip1 is sequestered and its activity gradually decreases as cells reach S phase. The addition of TGF-beta in early G1 blocks this decline in activity, by preventing the sequestration of Kip1. TGF-beta also reduces the levels of Cdk4. Kip1 preferentially binds Cyclin D-Cdk4, but the lower levels of Cdk4 in TGF-beta treated cells allow Kip1 to be available for binding to Cyclin E-Cdk2 and Cyclin A-Cdk2. Kip1 is structurally related to Cip1/WAF1, having a similar 60 amino acid sequence in the N-terminal region. A 52 amino acid Kip1 peptide (residues 28-79) from this region is sufficient to inhibit cdk activity in vitro. This antibody is routinely tested by western blot analysis.
Molecular Weight 27 kDa

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Polyak, Lee, Erdjument-Bromage et al.: "Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals." in: Cell, Vol. 78, Issue 1, pp. 59-66, 1994 (PubMed).

Polyak, Kato, Solomon et al.: "p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest." in: Genes & development, Vol. 8, Issue 1, pp. 9-22, 1994 (PubMed).

Frey, Clark, Leontieva et al.: "Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium." in: The Journal of cell biology, Vol. 151, Issue 4, pp. 763-78, 2000 (PubMed).

Barnouin, Dubuisson, Child et al.: "H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13761-70, 2002 (PubMed).

Williamson, Dadmanesh, Koeffler: "BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1)." in: Oncogene, Vol. 21, Issue 20, pp. 3199-206, 2002 (PubMed).

Guo, Packard, Krolewski et al.: "Expression of pax6 and sox2 in adult olfactory epithelium." in: The Journal of comparative neurology, Vol. 518, Issue 21, pp. 4395-418, 2010 (PubMed).

Alternatives for antigen "Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B)", type "Antibodies"
Hosts (302), (64), (16), (2), (1)
Reactivities (344), (172), (146), (83), (61), (54), (36), (14), (4), (3), (2), (2), (2), (1), (1), (1), (1)
Applications (261), (134), (100), (69), (60), (55), (29), (18), (13), (11), (8), (5), (2), (1)
Conjugates (13), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (2), (2)
Epitopes (58), (42), (26), (24), (21), (20), (12), (8), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)