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CDKN1B antibody (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)) pThr187 Primary Antibody

CDKN1B Reactivity: Human, Mouse, Rat ELISA, ICC, IF, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6256493
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  • Target See all CDKN1B Antibodies
    CDKN1B
    Binding Specificity
    • 39
    • 28
    • 21
    • 20
    • 18
    • 16
    • 12
    • 11
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr187
    Reactivity
    • 315
    • 147
    • 128
    • 42
    • 10
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 251
    • 65
    • 14
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 263
    • 71
    Polyclonal
    Conjugate
    • 139
    • 26
    • 23
    • 19
    • 18
    • 16
    • 16
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CDKN1B antibody is un-conjugated
    Application
    • 223
    • 162
    • 89
    • 76
    • 58
    • 49
    • 33
    • 30
    • 22
    • 16
    • 11
    • 8
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Phospho-p27 Kip1 (Thr187) Antibody detects endogenous levels of p27 Kip1 only when phosphorylated at Threonine 187.
    Predicted Reactivity
    Bovine,Sheep,Rabbit,Dog,Chicken
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human p27 Kip1 around the phosphorylation site of Thr187.
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    CDKN1B
    Alternative Name
    CDKN1B (CDKN1B Products)
    Synonyms
    CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cdkn1b, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18e03, CDKN1B, Kip1, p27, FAM14D, ISG12, ISG12A, P27, Cdki1b, AA408329, AI843786, p27Kip1, cdkn1bl, cyclin dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1Bb, interferon alpha inducible protein 27, cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1Ba, CDKN1B, cdkn1bb, IFI27, Cdkn1b, cdkn1ba
    Background

    Description: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

    Gene: CDKN1B

    Molecular Weight
    27kDa
    Gene ID
    UniProt
    P46527
    Pathways
    Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
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