Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 892-1051) antibody

Details for Product No. ABIN967955
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Antigen
Synonyms NMDAR2B, GluN2B, MRD6, NR2B, hNR3, nmdar2b, nr2b, AW490526, Nmdar2b
Epitope
AA 892-1051
(50), (43), (41), (38), (36), (27), (22), (22), (17), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(313), (292), (256), (138), (136), (135), (70), (17), (8), (7), (4), (3), (3), (2), (2)
Host
Mouse
(302), (57), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(11), (11), (11), (9), (9), (9), (9), (9), (9), (9), (9), (6), (6), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
(231), (114), (86), (79), (71), (70), (52), (38), (18), (11), (4), (1)
Pubmed 5 references available
Quantity 50 µg
Options
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Catalog No. ABIN967955
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Immunogen Rat NMDAR2B
Clone 7H3
Isotype IgG2b
Cross-Reactivity Human, Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name NMDAR2B
Background The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distint types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. Three types of NMDAR2 have been identified: NR2A, NR2B, and NR2C. NR2A and NR2B contain a C-terminal extension (>600 amino acids) that has small scattered regions of conserved sequence. The three NR2 mRNAs show overlapping, differential expression patterns in the rat brain. NR2B has been reported to be expressed in the forebrain, thalamic nuclei, amygdaloid nuclei, caudateputamen, and in restricted regions of the olfactory bulb. This antibody is routinely tested by western blot analysis.
Synonyms: N-Methyl-D-Aspartate Receptor 2B
Molecular Weight 180 kDa
Research Area Neurology, Neurotransmitters, Receptors
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 892-1051) antibody Western blot analysis of NMDAR2B on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti- NMDAR2B antibody.
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 892-1051) antibody (2) Immunofluorescence staining of a rabbit brain section.
Product cited in: Monyer, Sprengel, Schoepfer et al.: "Heteromeric NMDA receptors: molecular and functional distinction of subtypes." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1217-21, 1992 (PubMed).

Sun, Murali: "Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate." in: The American journal of physiology, Vol. 275, Issue 3 Pt 1, pp. C772-9, 1998 (PubMed).

Fallon, Moreau, Croft et al.: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Wong, Setou, Teng et al.: "Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14500-5, 2002 (PubMed).

Yoshii, Sheng, Constantine-Paton: "Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1334-9, 2003 (PubMed).

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