Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 9-204) antibody

Details for Product No. ABIN968570
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Antigen
Synonyms MGC53951, slc3a2, MGC53965, SLC3A2, 4F2, 4F2HC, AI314110, Cd98, Ly-10, Ly-m10, Ly10, Mdu1, Mgp-2hc, NACAE, 4T2HC, CD98, CD98HC, MDU1, 4F2LC, D16S469E, E16, LAT1, MPE16, hLAT1
Epitope
AA 9-204
(8), (7), (6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(114), (56), (16), (12), (12)
Host
Mouse
(75), (50), (27), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(29), (15), (11), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(102), (35), (35), (29), (22), (18), (16), (10), (6), (6), (6), (2), (1)
Pubmed 4 references available
Quantity 50 μg
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Catalog No. ABIN968570
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Immunogen Rat 4F2 hc
Clone OPG-13
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD98HC
Background 4F2 antigen (CD98) was identified as a heterodimer consisting of an 80 kDa type II glycosylated integral membrane protein 4F2 heavy chain (4F2 hc) linked by disulfide bonds to a hydrophobic, non-glycosylated, 37 kDa protein 4F2 light chain (4F2 lc). The 4F2 hc colocalizes with cadherins at cell adhesion sites and is required for the intracellular targeting of 4F2 heterodimers. 4F2 hc also associates with beta1 integrins and overexpression of 4F2 reverses the suppression of beta1 integrin activation caused by overexpression of beta1 cytoplasmic domains. 4F2 has also been identified as a fusion regulatory protein FRP-1, since anti-FRP-1 antibodies can induce HIV-mediated cell fusion via an integrin system. 4F2 heterodimers are also important for activation of amino acid transport. 4F2 hc is 30% homologous with the amino acid transport activator D2/rBAT and expression of 4F2 hc in Xenopus oocytes induces system y+L amino acid transport. Thus, 4F2 hc may participate in intracellular trafficking and activation of amino acid transporters, as well as in the regulation of integrin signaling.
Synonyms: 4F2 hc
Molecular Weight 80 kDa
Comment

Related Products: ABIN967389, ABIN968548

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 9-204) antibody Western blot analysis of CD98HC on rat liver lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution on CD98HC.
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 9-204) antibody (2) Chick Fibroblast
anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 9-204) antibody (3) anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 9-204) antibody (Image 3)
Product cited in: Fenczik, Sethi, Ramos et al.: "Complementation of dominant suppression implicates CD98 in integrin activation." in: Nature, Vol. 390, Issue 6655, pp. 81-5, 1997 (PubMed).

Kanai, Segawa, Miyamoto et al.: "Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 23629-32, 1998 (PubMed).

Nakamura, Sato, Yang et al.: "4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer." in: The Journal of biological chemistry, Vol. 274, Issue 5, pp. 3009-16, 1999 (PubMed).

Tsurudome, Ito, Takebayashi et al.: "Cutting edge: primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 2462-6, 1999 (PubMed).

Validation Images
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