NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 620-732) antibody

Details for Product No. ABIN968688
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Antigen
Synonyms E330007A02Rik, NBS1, Nalp2, PAN1, PYPAF2, CLR19.9, NALP2, NLRP2
Epitope
AA 620-732
(16), (7), (5), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(52), (39), (24), (1), (1), (1)
Host
Mouse
(58), (3), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(51), (25), (16), (10), (5), (4), (3), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN968688
Quantity 50 µg
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Immunogen Human NBS1
Clone L10CC10
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name NBS1
Background Nijmegen Breakage Syndrome (NBS) is characterized by extreme radiation sensitivity and chromosomal instability. The NBS1 gene product, p95/nibrin/NBS1, forms a complex with Rad50 and Mre11. Cells deficient in this complex have problems with DNA double-strand break repair, cell cycle checkpoint control, and telomere length maintenance. NBS1 contains a forkhead-associated domain (FHA) and a breast cancer carboxy-terminal domain (BRCT) in the N-terminal region. Both of these domains have been found in DNA-damage responsive cell cycle checkpoint proteins. The complex containing NBS1, Rad50, and Mre11 possesses manganese-dependent single stranded DNA endonuclease and 3' to 5' exonuclease activities. In addition, NBS1 is required for DNA-damage dependent phosphorylation of Mre11. This phosphorylation may be required for proper nuclear localization of the NBS1-Rad50-Mre11 complex to sites of DNA double-strand breaks. NBS1 interacts directly with telomere repeat binding factor, TRF1, via its C-terminal region, and both NBS1 and Mre11 co-localize with TRF1 at promyelocytic leukemia nuclear bodies. Thus, the NBS1-Rad50-Mre11 complex may be important for both DNA damage repair, and telomere length maintenance.
Synonyms: Nijmegen Breakage Syndrome-1
Molecular Weight 95 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 620-732) antibody Western blot analysis of NBS1 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-NBS1 antibody.
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 620-732) antibody (2) Immunofluorescence staining of L6 cells (Rat skeletal muscle myoblasts, ATCC CRL-1458).
Product cited in: Carney, Maser, Olivares et al.: "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response." in: Cell, Vol. 93, Issue 3, pp. 477-86, 1998 (PubMed).

Trujillo, Yuan, Lee et al.: "Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95." in: The Journal of biological chemistry, Vol. 273, Issue 34, pp. 21447-50, 1998 (PubMed).

Dong, Zhong, Chen: "The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19513-6, 1999 (PubMed).

Kim, Krasieva, LaMorte et al.: "Specific recruitment of human cohesin to laser-induced DNA damage." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45149-53, 2002 (PubMed).

Hosts (58), (3), (1), (1)
Reactivities (52), (39), (24), (1), (1), (1)
Applications (51), (25), (16), (10), (5), (4), (3), (2), (1), (1)
Conjugates (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (7), (5), (2), (2), (1), (1), (1), (1), (1)
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