NLRP2 antibody (AA 1-220)

Catalog No. ABIN7160825

Product Details anti-NLRP2 Antibody

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Binding Specificity: AA 1-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human NACHT, LRR and PYD domains-containing protein 2 protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NLRP2

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Alternative Name: NLRP2 (NLRP2 Products)

Synonyms: CLR19.9 antibody, NALP2 antibody, NBS1 antibody, PAN1 antibody, PYPAF2 antibody, NLRP2 antibody, E330007A02Rik antibody, Nalp2 antibody, NLR family pyrin domain containing 2 antibody, NACHT, LRR and PYD domains-containing protein 2 antibody, NLR family pyrin domain containing 7 antibody, NLR family, pyrin domain containing 2 antibody, NLRP2 antibody, LOC100301026 antibody, LOC100387349 antibody, NLRP7 antibody, Nlrp2 antibody

Background:

Background: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Aliases: CLR19.9 antibody, FLJ20510 antibody, Leucine rich repeat and PYD containing protein 2 antibody, LRR and PYD domains-containing protein 2 antibody, NACHT antibody, NACHT domain antibody, NACHT leucine rich repeat and PYD containing 2 antibody, NACHT LRR and PYD domains containing protein 2 antibody, NALP2 antibody, NALP2_HUMAN antibody, NBS1 antibody, NLR family pyrin domain containing 2 antibody, NLRP2 antibody, Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody, Nucleotide-binding site protein 1 antibody, PAN1 antibody, PYPAF2 antibody, PYRIN containing APAF1 like protein2 antibody, PYRIN domain and NACHT domain-containing protein 1 antibody, PYRIN-containing APAF1-like protein 2 antibody

UniProt: Q9NX02

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome