NLRP2 antibody

Catalog No. ABIN363311

Product Details anti-NLRP2 Antibody

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reactivity: Human, Mouse, Hamster, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Reacts with NBS1 from human, mouse, hamster and primate

Purification: Antiserum

Immunogen: Partial length human NBS1 protein [Swiss-Prot# O60934].

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- ICC : 1/50 to 1/200 - IF : 1/200 - IP : 3 μL - WB : 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: , Sodium azide 0.02 %

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Target Details for NLRP2

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Alternative Name: Nijmegen Breakage Syndrome 1 (NBS1) (NLRP2 Products)

Synonyms: CLR19.9 antibody, NALP2 antibody, NBS1 antibody, PAN1 antibody, PYPAF2 antibody, NLRP2 antibody, E330007A02Rik antibody, Nalp2 antibody, NLR family pyrin domain containing 2 antibody, NACHT, LRR and PYD domains-containing protein 2 antibody, NLR family pyrin domain containing 7 antibody, NLR family, pyrin domain containing 2 antibody, NLRP2 antibody, LOC100301026 antibody, LOC100387349 antibody, NLRP7 antibody, Nlrp2 antibody

Background: The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex.This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome