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Details for Product No. ABIN968766

Lamin A/C (LMNA) (AA 398-490) antibody

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Antigen
Synonyms	CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, lmna-A, 2459, 74/76, CG6944, D5, DM[[O]], Dm, Dm(0), Dm0, Dm1, Dm2, DmLamin, DmO, Dm[[0]], Dm ... show more CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, lmna-A, 2459, 74/76, CG6944, D5, DM[[O]], Dm, Dm(0), Dm0, Dm1, Dm2, DmLamin, DmO, Dm[[0]], Dm[[1]], Dm[[2]], Dm[[mit]], Dm[[o]], Dmel\\CG6944, Dmo, LAM, Lam Dm[[0]], Lam(Dm0), LamDm[[0]], LamDm[[o]], Lam[[Dm0]], Lamin Dm[[0]], jf27, l(2)04643, l(2)25Ec, l(2)gdh-7, l(2)gdh7, l(2)jf27, lam, lamDm0, lamDm[[0]], lamin, lamin Dm0, lamin Dm[[0]], misg, nlam, cb948, fk66d12, wu:fk66d12, fpl, idc, lfp, cddc, emd2, fpld, hgps, ldp1, lmn1, lmnc, pro1, cdcd1, cmd1a, cmt2b1, lgmd1b, Lamin-A show less
Epitope	Alternatives AA 398-490 (13), (7), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity	Alternatives Human (139), (97), (88), (41), (31), (27), (10), (3), (2), (2), (2), (1), (1), (1), (1)
Host	Alternatives Mouse (96), (57), (3)
Clonality (Clone)	Monoclonal ()
Conjugate	Alternatives Un-conjugated (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Application	Alternatives Western Blotting (WB), Immunofluorescence (IF) (125), (58), (40), (38), (31), (30), (27), (23), (17), (16), (3), (1), (1)
	3 references available

Catalog no.	ABIN968766
Quantity	150 µg
Price	Contact our Customer Service for availability and price in your country.

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Product details

Alternative Name	Lamin A/C
Background	The nuclear envelope (NE) is a specialized extension of the ER that contains numerous pore complexes interconnected with the nuclear lamina. The nuclear lamina composes the structural framework for the NE and serves as a chromatin anchor site, thus playing a major role in interphase nuclear organization. The major component of nuclear lamina are intermediate filament-like proteins called lamins. In mammalian somatic cells, there are three major lamins, A, B1, and C, and two minor lamins, B2 and A10. A-type lamins (A, A10, and C) are encoded by a single gene and are produced by alternative splicing, while B-type lamins (B1 and B2) are encoded by separate genes. B-type lamins are found in all nucleated somatic cells, while the expression of A-type lamins are developmentally regulated. Mice lacking lamin A show no overt abnormalities until postnatal development when perturbations in nuclear envelop structure correlate with the appearance of muscular dystrophy. In addition, lamin A is mutated in lipodystrophy, a disorder characterized by reduction in subcutaneous adipose tissue. Thus, lamin A and C may be important for nuclear envelope formation during postnatal cell differentiation. This antibody is routinely tested by western blot analysis.
Molecular Weight	65 & 74 kDa
Research Area	Cytoskeleton, Extracellular Matrix

Alternatives for antigen "Lamin A/C (LMNA)", type "Antibodies"

Immunogen	Human Lamin A/C
Clone	Ghr2
Isotype	IgG1
Cross-Reactivity	Human, Chicken, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics	1. Since applications vary, each investigator should titrate the reagent to obtain optimal results. 2. Please refer to us for technical protocols. 3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. 4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification	Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity	Purified

Comment	Related Products: ABIN968535, ABIN967389
Restrictions	For Research Use only

Format	Liquid
Concentration	250 µg/ml
Buffer	Aqueous buffered solution containing BSA, glycerol.
Preservative	Sodium azide
Storage	-20 °C

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