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Lamin A/C antibody (pSer392)

LMNA Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6256311
  • Target See all Lamin A/C (LMNA) Antibodies
    Lamin A/C (LMNA)
    Binding Specificity
    • 10
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer392
    Reactivity
    • 147
    • 81
    • 76
    • 26
    • 15
    • 13
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 112
    • 43
    • 3
    • 1
    Rabbit
    Clonality
    • 107
    • 52
    Polyclonal
    Conjugate
    • 113
    • 11
    • 9
    • 8
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Lamin A/C antibody is un-conjugated
    Application
    • 125
    • 54
    • 51
    • 48
    • 32
    • 29
    • 28
    • 24
    • 13
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Phospho-Lamin A/C (Ser392) Antibody detects endogenous levels of Lamin A/C only when phosphorylated at Serine 392.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Rabbit,Chicken,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human Lamin A/C around the phosphorylation site of Ser392.
    Isotype
    IgG
    Top Product
    Discover our top product LMNA Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    Lamin A/C (LMNA)
    Alternative Name
    LMNA (LMNA Products)
    Synonyms
    CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, LMN1 antibody, LMNC antibody, LMNL1 antibody, PRO1 antibody, Dhe antibody, 2459 antibody, 74/76 antibody, CG6944 antibody, D5 antibody, DM[[O]] antibody, Dm antibody, Dm(0) antibody, Dm0 antibody, Dm1 antibody, Dm2 antibody, DmLamin antibody, DmO antibody, Dm[[0]] antibody, Dm[[1]] antibody, Dm[[2]] antibody, Dm[[mit]] antibody, Dm[[o]] antibody, Dmel\\CG6944 antibody, Dmo antibody, LAM antibody, Lam Dm[[0]] antibody, Lam(Dm0) antibody, LamDm[[0]] antibody, LamDm[[o]] antibody, Lam[[Dm0]] antibody, Lamin Dm[[0]] antibody, jf27 antibody, l(2)04643 antibody, l(2)25Ec antibody, l(2)gdh-7 antibody, l(2)gdh7 antibody, l(2)jf27 antibody, lam antibody, lamDm0 antibody, lamDm[[0]] antibody, lamin antibody, lamin Dm0 antibody, lamin Dm[[0]] antibody, misg antibody, nlam antibody, cb948 antibody, fk66d12 antibody, wu:fk66d12 antibody, lmna-A antibody, fpl antibody, idc antibody, lfp antibody, cddc antibody, emd2 antibody, fpld antibody, hgps antibody, ldp1 antibody, lmn1 antibody, lmnc antibody, pro1 antibody, cdcd1 antibody, cmd1a antibody, cmt2b1 antibody, lgmd1b antibody, Lamin-A antibody, lamin-L(III)-like antibody, lamin A/C antibody, lamin A antibody, Lamin antibody, lamin A/C L homeolog antibody, lamin-L(III)-like antibody, LMNA antibody, Lmna antibody, Lam antibody, lmna antibody, lmna.L antibody, LMINA antibody
    Background

    Description: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920).

    Gene: LMNA

    Molecular Weight
    74,65kDa
    Gene ID
    4000
    UniProt
    P02545
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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