Lamin A/C antibody (C-Term)

Catalog No. ABIN6254178

The Goat Polyclonal anti-Lamin A/C antibody (ABIN6254178) specifically detects Lamin A/C in WB and IF. The antibody is reactive with Human, Mouse, Rat, Cow, Pig, Dog, Monkey, Rabbit, Horse, Chicken, Hamster, Sheep, Guinea Pig, Avian, Cat, Donkey and Goat samples.

Quick Overview for Lamin A/C antibody (C-Term) (ABIN6254178)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Monkey, Rabbit, Horse, Chicken, Hamster, Sheep, Guinea Pig, Avian, Cat, Donkey, Goat

Host: Goat

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Lamin A/C Antibody

Binding Specificity: C-Term

Purpose: Anti-LMNA

Sequence: SASSVTVTRS YRSVGGSGGG SFGDNLVTRS YLLGNSSPRT QSPQNCSIM

Specificity: Detects a band of 65-70 kDa by Western blot in whole cell lysates.

Characteristics: Lamin A/C

Purification: Epitope affinity purified

Immunogen: Purified recombinant peptide within residues 620 aa to C-term of human LMNA produced in E. coli.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:5,000, IF:1:100-1:1,000

Restrictions: For Research Use only

Handling

Buffer: PBS, 20 % glycerol and 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: The antibody solution should be gently mixed before use.

Storage: 4 °C,-20 °C

Storage Comment: For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA

Background:

Goat polyclonal to LMNA (Lamin A/C) - nucleus marker. The Lamin family of proteins make up the matrix of proteins located next to the inner nuclear membrane. During mitosis, the lamina matrix is reversibly disassembled as the Lamin proteins are phosphorylated. These proteins are thought to be involved in chromatin structure, nuclear stability and gene expression.

CDDC, CDCD1, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2 HGPS, IDC, LDP1, LFP, LGMD1B, LMNC, LMN1, LMNL1, PRO1 antibody.

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus