Lamin A/C antibody (AA 455-469)

Catalog No. ABIN3031585

This Rabbit Polyclonal antibody specifically detects Lamin A/C in WB, ICC and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Lamin A/C antibody (AA 455-469) (ABIN3031585)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Lamin A/C Antibody

Binding Specificity: AA 455-469

Purpose: Lamin A/C Antibody

Sequence: RNKSNEDQSM GNWQI

Purification: Antigen affinity

Immunogen: Amino acids 455-469 (RNKSNEDQSMGNWQI) were used as the immunogen for this Lamin A/C antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Lamin A/C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C

Background: Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The Lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Protein deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus