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NMDAR2A antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a) (AA 1093-1214)

Details for Product anti-GRIN2A Antibody No. ABIN968802, Supplier: Login to see
Antigen
  • NMDAR2A
  • nr2a
  • GRIN2A
  • EPND
  • GluN2A
  • NR2A
Epitope
AA 1093-1214
76
69
34
30
15
15
14
12
11
8
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
139
114
84
3
3
3
1
1
Host
Mouse
138
74
4
Clonality (Clone)
Monoclonal ()
Conjugate
This NMDAR2A antibody is un-conjugated
13
13
11
8
8
8
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
174
130
57
39
25
23
20
16
10
3
1
1
1
Supplier
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Immunogen Mouse NMDAR2A aa. 1093-1214
Clone 5-NMDAR2A
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name NMDAR2A (GRIN2A Antibody Abstract)
Background The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups, ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. Four types of NMDAR2 have been identified: NMDAR2A (NR2A), NR2B, NR2C, and NR2D. NR2A and NR2B contain a C-terminal extension (> 600 amino acids) that has small, scattered regions of conserved sequence. In embryonic stages, NR2B is expressed throughout the brain, while NR2D is found in diencephalon and brainstem. After birth, NR2A is found throughout the brain, and NR2C is expressed in cerebellum. At this time, NR2B expression becomes restricted to the forebrain, and NR2D expression is strongly reduced. Deletion of the most widespread postnatal NR subunit, NR2A, does not have adverse affects on brain development, but reduces long-term potentiation (LTP) in the hippocampus and impairs spatial and contextual learning. Thus, NR2A may be critical for postnatal learning. This antibody is routinely tested by western blot analysis.
Synonyms: N-Methyl D-Aspartate
Molecular Weight 180 kDa
Research Area Neurology
Pathways
Comment

Related Products: ABIN968540, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-NMDAR2A antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a) (AA 1093-1214) (ABIN968802) Western blot analysis of NMDAR2A on a mouse cerebrum lysate. Lane 1: 1:500, lane 2: 1...
Product cited in: Morikawa, Mori, Kiyama et al.: "Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 23, pp. 9727-32, 1998 (PubMed).

Ishii, Moriyoshi, Sugihara et al.: "Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits." in: The Journal of biological chemistry, Vol. 268, Issue 4, pp. 2836-43, 1993 (PubMed).