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Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) (AA 1093-1214) antibody

Details for Product No. ABIN968802
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Antigen
Synonyms NMDAR2A, nr2a, GRIN2A, EPND, GluN2A, NR2A
Epitope
AA 1093-1214
(40), (38), (19), (18), (13), (7), (7), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(89), (88), (53), (46), (32), (31), (30), (3), (1)
Host
Mouse
(107), (41), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (7), (7), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(104), (66), (38), (24), (23), (18), (12), (8), (3), (2), (1)
Pubmed 2 references available
Quantity 50 µg
Options
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Catalog No. ABIN968802
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Immunogen Mouse NMDAR2A
Clone 5
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name NMDAR2A
Background The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups, ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. Four types of NMDAR2 have been identified: NMDAR2A (NR2A), NR2B, NR2C, and NR2D. NR2A and NR2B contain a C-terminal extension (> 600 amino acids) that has small, scattered regions of conserved sequence. In embryonic stages, NR2B is expressed throughout the brain, while NR2D is found in diencephalon and brainstem. After birth, NR2A is found throughout the brain, and NR2C is expressed in cerebellum. At this time, NR2B expression becomes restricted to the forebrain, and NR2D expression is strongly reduced. Deletion of the most widespread postnatal NR subunit, NR2A, does not have adverse affects on brain development, but reduces long-term potentiation (LTP) in the hippocampus and impairs spatial and contextual learning. Thus, NR2A may be critical for postnatal learning. This antibody is routinely tested by western blot analysis.
Synonyms: N-Methyl D-Aspartate
Molecular Weight 180 kDa
Research Area Neurology
Comment

Related Products: ABIN968540, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) (AA 1093-1214) antibody Western blot analysis of NMDAR2A on a mouse cerebrum lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the anti- NMDAR2A antibody.
Product cited in: Ishii, Moriyoshi, Sugihara et al.: "Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits." in: The Journal of biological chemistry, Vol. 268, Issue 4, pp. 2836-43, 1993 (PubMed).

Morikawa, Mori, Kiyama et al.: "Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 23, pp. 9727-32, 1998 (PubMed).

Validation Images
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