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Bcl-2 antibody

BCL2 Reactivity: Human, Mouse IHC, FACS, ELISA, ICC Host: Mouse Monoclonal 8E12 unconjugated
Catalog No. ABIN968975
  • Target See all Bcl-2 (BCL2) Antibodies
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Reactivity
    • 404
    • 164
    • 163
    • 34
    • 23
    • 22
    • 15
    • 9
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 323
    • 111
    • 5
    • 2
    • 1
    Mouse
    Clonality
    • 320
    • 121
    Monoclonal
    Conjugate
    • 196
    • 28
    • 27
    • 21
    • 20
    • 12
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This Bcl-2 antibody is un-conjugated
    Application
    • 334
    • 176
    • 140
    • 107
    • 95
    • 91
    • 80
    • 60
    • 54
    • 29
    • 23
    • 22
    • 18
    • 8
    • 8
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)
    Purpose
    BCL-2 Antibody
    Purification
    Ascitic fluid
    Immunogen
    Synthetic peptide corresponding to residues surrounding BCL-2, conjugated to KLH.
    Clone
    8E12
    Isotype
    IgG1
    Top Product
    Discover our top product BCL2 Primary Antibody
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Choi, Feng, Yoon: "FKBP38 protects Bcl-2 from caspase-dependent degradation." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9770-9, (2010) (PubMed).

    Munda, Hajdinjak, Kavalar, Stiblar Martincic: "p53, Bcl-2 and AgNOR tissue markers: model approach in predicting prostate cancer characteristics." in: The Journal of international medical research, Vol. 37, Issue 6, pp. 1868-76, (2010) (PubMed).

    Murphy, Green, Adams, Squire, Kuo, McKay: "Pharmacogenomics in the curricula of colleges and schools of pharmacy in the United States." in: American journal of pharmaceutical education, Vol. 74, Issue 1, pp. 7, (2010) (PubMed).

  • Target
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Alternative Name
    BCL-2 (BCL2 Products)
    Background

    Description: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.Tissue specificity: Expressed in a variety of tissues.

    Aliases: Bcl-2, BCL2

    Molecular Weight
    26kDa
    Gene ID
    596
    HGNC
    596
    UniProt
    P10415
    Pathways
    MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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