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Details for Product No. ABIN969315

Nerve Growth Factor Receptor (NGFR) antibody

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Antigen
Synonyms CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, ngfr, wu:fb38c02, wu:fc10h01, NRH1b, fullback, nrh1, p75ntr, tnfrsf16
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 3 references available
Catalog no. ABIN969315
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human NGFR expressed in E. coli.
Clone 2F1C2
Isotype IgG1
Purification Ascites
Alternative Name NGFR
Background Synonyms:
CD271, p75NTR, TNFRSF16, p75 (NTR), Gp80-LNGFR, NGFR
Nerve growth factor receptor contains an extracellular domain containing four 40 AA repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155 AA cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF κB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).
Molecular Weight 45 kDa
Gene ID 4804
Research Area Growth Factors, Receptors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: DiDonato, Hayakawa, Rothwarf et al.: "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB." in: Nature, Vol. 388, Issue 6642, pp. 548-54, 1997 (PubMed).

Hu, Zhang, Qin et al.: "Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients." in: Experimental neurology, Vol. 178, Issue 1, pp. 104-11, 2002 (PubMed).

He, Garcia: "Structure of nerve growth factor complexed with the shared neurotrophin receptor p75." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 870-5, 2004 (PubMed).

Alternatives for antigen "Nerve Growth Factor Receptor (NGFR)", type "Antibodies"
Hosts (89), (66), (12), (4), (1)
Reactivities (134), (68), (65), (37), (14), (14), (13), (11), (5), (5), (4), (3)
Applications (109), (62), (56), (53), (40), (33), (30), (26), (20), (20), (5), (4), (3), (1), (1), (1)
Conjugates (8), (7), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (7), (6), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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