p63alpha antibody

Catalog No. ABIN969337

This Mouse Monoclonal antibody specifically detects in WB, IHC and ELISA. It exhibits reactivity toward Human, Monkey, Mouse and Rat and has been mentioned in 2+ publications.

Quick Overview for p63alpha antibody (ABIN969337)

Target: p63alpha

Reactivity: Human, Monkey, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 4E5

Product Details

Purpose: p63a Antibody

Purification: Ascitic fluid

Immunogen: Synthesized peptide of human p63alpha.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References

King, Ponnamperuma, Allen, Lu, Duggal, Chen, Van Waes, Weinberg: "The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth." in: Cancer research, Vol. 68, Issue 13, pp. 5122-31, (2008) (PubMed).

Valenzise, Arrigo, De Luca, Privitera, Frigiola, Carando, Garelli, Silengo: "R298Q mutation of p63 gene in autosomal dominant ectodermal dysplasia associated with arrhythmogenic right ventricular cardiomyopathy." in: European journal of medical genetics, Vol. 51, Issue 5, pp. 497-500, (2008) (PubMed).

Target Details

Target: p63alpha

Alternative Name: p63a

Background: The p63 gene is a homologue of the p53 tumor suppressor gene. Like p53, p63 contains a transactivation (TA) domain induce the transcription of target genes, a DNA binding domain, and an oligomerization domain (OD), used to form tetramers. In contrast to p53, the p63 gene encodes for at least six major isotypes. Three isotypes (TAp63a, TAp63

Molecular Weight: 51 kDa

Gene ID: 8626

UniProt: Q9H3D4