EPH Receptor B6 (EPHB6) antibody

Details for Product No. ABIN969479
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Antigen
Synonyms CEK9, EPHB5, Cekl, Mep, HEP
Reactivity
Human
(97), (35), (29), (13), (12)
Host
Mouse
(73), (22), (4), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(78), (55), (40), (22), (15), (12), (10), (6), (4), (3), (1), (1)
Pubmed 2 references available
Quantity 100 μL
Options
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Catalog No. ABIN969479
451.00 $
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Immunogen Purified recombinant fragment of EphB6 expressed in E. coli.
Clone 8E7H12
Isotype IgG1
Purification Purified
Alternative Name EphB6
Background Synonyms:
HEP, MGC129910, MGC129911
EPH receptor B6 (EphB6), with 1006 AA protein (approx. 110 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Eph receptors and ephrin ligands are membrane-bound cell-cell communication molecules with well-defined functions in development. EphB6 is expressed both in a variety of embryonic and adult tissues. EphB6 is a unique member in the Eph family of receptor tyrosine kinases in that its kinase domain contains several alterations in conserved AA and is catalytically inactive. EphB6 can both positively and negatively regulate cell adhesion and migration and tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition.
Gene ID 2051
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-EPH Receptor B6 (EPHB6) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded human bladder carcinoma (left) and return carcinoma (right) tissue, showing cytoplasmic localization using EphB6 mouse mAb with DAB staining.
anti-EPH Receptor B6 (EPHB6) antibody (2) Figure 1: Western blot analysis of Jurkat (1) and NIH/3T3 (2) cell lysate using EphB6 mouse mAb.
Product cited in: Matsuoka, Obama, Kelly et al.: "Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration." in: The Journal of biological chemistry, Vol. 280, Issue 32, pp. 29355-63, 2005 (PubMed).

Ogawa, Wada, Okada et al.: "EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases." in: Journal of cell science, Vol. 119, Issue Pt 3, pp. 559-70, 2006 (PubMed).

Validation Images
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