EPH Receptor B6 antibody (C-Term)

Catalog No. ABIN391928

There are 3+ publications for this product available. The Rabbit Polyclonal anti-EPH Receptor B6 antibody is suitable to detect EPH Receptor B6 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for EPH Receptor B6 antibody (C-Term) (ABIN391928)

Target: EPH Receptor B6 (EPHB6)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1666

Product Details anti-EPH Receptor B6 Antibody

Binding Specificity: AA 990-1021, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 990-1021 amino acids from the C-terminal region of human EphB6.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-EPH Receptor B6 antibody (ABIN391928)

Gu, Li, Qian, Chen, Wang, Wang: "Expression of EphB6 in ovarian serous carcinoma is associated with grade, TNM stage and survival." in: Journal of clinical pathology, (2015) (PubMed).

Brantley-Sieders, Jiang, Sarma, Badu-Nkansah, Walter, Shyr, Chen: "Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome." in: PLoS ONE, Vol. 6, Issue 9, pp. e24426, (2011) (PubMed).

Yu, Bulk, Ji, Hascher, Tang, Metzger, Marra, Serve, Berdel, Wiewroth, Koschmieder, Müller-Tidow: "The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 8, pp. 2275-83, (2010) (PubMed).

Target Details for EPH Receptor B6

Target: EPH Receptor B6 (EPHB6)

Alternative Name: EphB6

Background: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

Molecular Weight: 110700

Gene ID: 2051

NCBI Accession: NP_001267723, NP_001267724, NP_004436

UniProt: O15197

Pathways: RTK Signaling, Hormone Transport