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Browse our anti-CFLAR (CFLAR) Antibodies

Full name:
anti-CASP8 and FADD-Like Apoptosis Regulator Antibodies (CFLAR)
On are 277 CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Antibodies from 27 different suppliers available. Additionally we are shipping CFLAR Proteins (12) and CFLAR Kits (5) and many more products for this protein. A total of 315 CFLAR products are currently listed.
2310024N18Rik, A430105C05Rik, c-Flip, c-FLIPL, c-FLIPR, c-FLIPS, Cash, CASP8AP1, Casper, CFLAR, CLARP, Clarp1, ENSMUSG00000072980, FLAME, FLAME-1, FLAME1, Flip, Gm9845, I-FLICE, MRIT
list all antibodies Gene Name GeneID UniProt
CFLAR 8837 O15519
CFLAR 12633 O35732
CFLAR 117279  

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Most Popular Reactivities for anti-CFLAR (CFLAR) Antibodies

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anti-Human CFLAR Antibodies:

anti-Mouse (Murine) CFLAR Antibodies:

anti-Rat (Rattus) CFLAR Antibodies:

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Top referenced anti-CFLAR Antibodies

  1. Human Polyclonal CFLAR Primary Antibody for IHC (p), WB - ABIN401040 : Thome, Schneider, Hofmann, Fickenscher, Meinl, Neipel, Mattmann, Burns, Bodmer, Schröter, Scaffidi, Krammer, Peter, Tschopp: Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. in Nature 1997 (PubMed)
    Show all 4 references for ABIN401040

  2. Human Polyclonal CFLAR Primary Antibody for IHC (fro), IF - ABIN318973 : Shu, Halpin, Goeddel: Casper is a FADD- and caspase-related inducer of apoptosis. in Immunity 1997 (PubMed)
    Show all 4 references for ABIN318973

  3. Mouse (Murine) Polyclonal CFLAR Primary Antibody for EIA, IF - ABIN499844 : Irmler, Thome, Hahne, Schneider, Hofmann, Steiner, Bodmer, Schröter, Burns, Mattmann, Rimoldi, French, Tschopp: Inhibition of death receptor signals by cellular FLIP. in Nature 1997 (PubMed)
    Show all 4 references for ABIN499844

  4. Human Monoclonal CFLAR Primary Antibody for FACS, IHC - ABIN1724850 : Bedolla, Gong, Prihoda, Yeh, Thompson, Ghosh, Kumar: Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence. in PLoS ONE 2012 (PubMed)
    Show all 2 references for ABIN1724850

  5. Human Monoclonal CFLAR Primary Antibody for EIA, WB - ABIN336100 : Yu, Shi: FLIP and the death effector domain family. in Oncogene 2008 (PubMed)
    Show all 2 references for ABIN336100

  6. Human Polyclonal CFLAR Primary Antibody for EIA, FACS - ABIN951489 : Kim, Pettingell, Jung, Kovacs, Tanzi: Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. in Science (New York, N.Y.) 1998 (PubMed)

  7. Human Polyclonal CFLAR Primary Antibody for WB - ABIN2792120 : Geserick, Drewniok, Hupe, Haas, Diessenbacher, Sprick, Schön, Henkler, Gollnick, Walczak, Leverkus: Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis. in Oncogene 2008 (PubMed)

  8. Cow (Bovine) Polyclonal CFLAR Primary Antibody for WB - ABIN2792098 : Kondo, Iwase, Watanabe, Uchida, Takaoka, Ohashi, Ito, Nagumo: Enhancement of susceptibility to Fas-mediated apoptosis in HL-60 cells through down-regulation of cellular FLICE-inhibitory protein by phosphatidylinositol 3-kinase inhibitors. in Oncology reports 2005 (PubMed)

More Antibodies against CFLAR Interaction Partners

Human CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. Data show that heterogeneous nuclear ribonucleoprotein K (hnRNPK (show HNRNPK Antibodies)) stabilized of cellular FLICE-inhibitory protein (c-FLIP) protein through inhibition of glycogen synthase kinase 3 beta (GSK3beta (show GSK3b Antibodies)) Ser9 phosphorylation during the TNF (show TNF Antibodies)-related aoptosis-inducing ligand (TRAIL)-induced apoptosis.

  2. Data indicate that FADD (show FADD Antibodies) mediated apoptotic cell death was directed by ubiquitination of cFLIPL and inhibition of NF-kappaB (show NFKB1 Antibodies) activation.

  3. cFLIP long form shRNA serves a specific inhibitory role in cellular proliferation through inducing the activation of the JNK (show MAPK8 Antibodies) pathway in A875 cells.

  4. Study demonstrated the function of FLIPL in facilitating hepatocellular carcinoma cells (HCC (show FAM126A Antibodies)) aerobic glycolysis by modulating SGLT1 (show SLC5A1 Antibodies)-mediated glucose uptake and FLIPL expression level was positively correlated with SGLT1 (show SLC5A1 Antibodies) expression level in patients with HCC (show FAM126A Antibodies).

  5. Data show that suppression of autophagy effectively attenuated cytotoxicity induced by Chal-24 and TRAIL combination, which was associated with attenuation of c-FLIP(L) protein and cellular inhibitor of apoptosis proteins (c-IAPs) degradation.

  6. neither c-FLIP nor procaspase-8 prodomain terminates the DED (show AATF Antibodies) chain, but rather the dissociation/association rates of procaspase-8 define the stability of the chain and thereby its length.

  7. Our findings suggested that GA induces apoptosis via the downregulation of cFLIPL and sensitized TRAIL-mediated apoptosis in Caki (show CASK Antibodies) cells.

  8. A dual role for cFLIP in the maintenance of breast cancer stem cell viability, dependent upon its subcellular distribution.

  9. This conservation of IKK (show CHUK Antibodies) activation among the cFLIP family using different mechanisms suggests that the mechanism plays a critical role in their function.

  10. procaspase-8:c-FLIPL exhibits localized enzymatic activity and is preferentially an activator, promoting DED (show AATF Antibodies)-mediated procaspase-8 oligomer assembly, whereas procaspase-8:c-FLIPS lacks activity and potently blocks procaspase-8 activation

Mouse (Murine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. CASP8 (show CASP8 Antibodies) is present exclusively as its cleaved p43 (show AIMP1 Antibodies) product, bound to cFLIPL.

  2. The generation of mouse line with Flip deficiency in cells that express cre under the CD11c (show ITGAX Antibodies) promoter is reported.

  3. c-FLIPL deficiency induces the caspase (show CASP3 Antibodies)-mediated processing of RTN4 (show RTN4 Antibodies), thus affecting endoplasmic reticulum (ER) shape and coupling to mitochondria. Thus, it was concluded that c-FLIPL is a novel regulator of ER morphology and ER-mitochondria crosstalk.

  4. Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.

  5. The results reveal a novel inhibitory role of c-FLIP in myeloid cell activation and demonstrate the unexpected anti-inflammatory activity of c-FLIP.

  6. Upon starvation, c-Flip affects lipid accumulation, ER stress and autophagy, thereby pointing to an important role of c-Flip in the adaptive response and ER stress response programs under both normal and pathological conditions.

  7. Flip preserves cardiac functions and inhibits cardiac hypertrophy partially by blocking ASK1 (show MAP3K5 Antibodies)/P38 (show CRK Antibodies) signaling.

  8. These data suggest that c-FLIP is a negative regulator of intrinsic apoptosis pathway in T lymphocytes.

  9. c-FLIPR is an important modulator of apoptosis and enforced expression leads to autoimmunity.

  10. cFLIP protein expression from one allele of cFLIP is sufficient to protect epidermal keratinocytes from cell death and a macroscopic phenotype upon acute ablation of the cFLIP locus.

Cow (Bovine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. results indicate downregulation of cFLIP during structural luteal regression, suggesting that cFLIP plays a survival role in the bovine corpus luteum

  2. Conservation of FLIP's ability to inhibit apoptosis and to downregulate NF-kappaB (show NFKB1 Antibodies) activation across species.

Pig (Porcine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) interaction partners

  1. cellular-Flice like inhibitory protein (cFLIP) long form, plays an anti-apoptotic role in the granulosa cells of healthy follicles of pig ovaries [cFLIP]

  2. Intracellular remodeling with overexpression of pig c (show PIGC Antibodies)-FLIP in xenograft cells may decrease the innate cellular responses against xenografts, facilitating long-term xenograft survival.

  3. Intracellular remodeling with the overexpression of c-FLIP(S/L) in xenograft cells may avoid innate cellular attacks against xenografts and facilitate long-term xenograft survival.

  4. Overexpression of c-FLIP in xenograft cells may prevent innate cellular attacks against xenografts opening the window of opportunity for long-term xenograft survival.

CFLAR Antigen Profile

Antigen Summary

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Alternative names and synonyms associated with CFLAR

  • CASP8 and FADD-like apoptosis regulator a (cflara) antibody
  • CASP8 and FADD-like apoptosis regulator (CFLAR) antibody
  • CASP8 and FADD-like apoptosis regulator (cflar) antibody
  • CASP8 and FADD-like apoptosis regulator (Cflar) antibody
  • cellular FLICE-like inhibitory protein (C-FLIP) antibody
  • 2310024N18Rik antibody
  • A430105C05Rik antibody
  • c-Flip antibody
  • c-FLIPL antibody
  • c-FLIPR antibody
  • c-FLIPS antibody
  • Cash antibody
  • CASP8AP1 antibody
  • Casper antibody
  • CFLAR antibody
  • CLARP antibody
  • Clarp1 antibody
  • ENSMUSG00000072980 antibody
  • FLAME antibody
  • FLAME-1 antibody
  • FLAME1 antibody
  • Flip antibody
  • Gm9845 antibody
  • I-FLICE antibody
  • MRIT antibody

Protein level used designations for CFLAR

FLIP , CASP8 and FADD-like apoptosis regulator , flice/caspase-i inhibitory protein , cellular FLICE-like inhibitory protein , CASP8 and FADD-like apoptosis regulator-like , FADD-like anti-apoptotic molecule , FADD-like antiapoptotic molecule 1 , MACH-related inducer of toxicity , caspase homolog , caspase-eight-related protein , caspase-like apoptosis regulatory protein , caspase-related inducer of apoptosis , inhibitor of FLICE , usurpin beta , usurpin , FLICE-like inhibitory protein

373114 Danio rerio
424080 Gallus gallus
459872 Pan troglodytes
574234 Macaca mulatta
779578 Xenopus (Silurana) tropicalis
780745 Xenopus laevis
100142680 Felis catus
100393782 Callithrix jacchus
100474872 Ailuropoda melanoleuca
100589650 Nomascus leucogenys
8837 Homo sapiens
12633 Mus musculus
488471 Canis lupus familiaris
497199 Bos taurus
117279 Rattus norvegicus
100172025 Pongo abelii
414381 Sus scrofa
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