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Browse our anti-Perforin 1 (PRF1) Antibodies

Full name:
anti-Perforin 1 (Pore Forming Protein) Antibodies (PRF1)
On are 179 Perforin 1 (Pore Forming Protein) (PRF1) Antibodies from 23 different suppliers available. Additionally we are shipping Perforin 1 Kits (71) and Perforin 1 Proteins (13) and many more products for this protein. A total of 272 Perforin 1 products are currently listed.
Cyta, FLH2, HPLH2, LOC443187, P1, perforin, Pfn, PFN1, Pfp, Prf-1, prf1, RATCYTA
list all antibodies Gene Name GeneID UniProt
PRF1 5551 P14222
PRF1 18646 P10820
PRF1 50669  

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anti-Human Perforin 1 Antibodies:

anti-Mouse (Murine) Perforin 1 Antibodies:

anti-Rat (Rattus) Perforin 1 Antibodies:

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Top referenced anti-Perforin 1 Antibodies

  1. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2657991 : Lieberman: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. in Nature reviews. Immunology 2003 (PubMed)
    Show all 11 references for ABIN2657991

  2. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2657572 : Trapani, Smyth: Functional significance of the perforin/granzyme cell death pathway. in Nature reviews. Immunology 2002 (PubMed)
    Show all 11 references for ABIN2657572

  3. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2658819 : Hameed, Olsen, Cheng, Fox, Hruban, Podack: Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody. in The American journal of pathology 1992 (PubMed)
    Show all 10 references for ABIN2658819

  4. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN2662106 : Barrat, Le Deist, Benkerrou, Bousso, Feldmann, Fischer, de Saint Basile: Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 10 references for ABIN2662106

  5. Human Monoclonal Perforin 1 Primary Antibody for IHC (fro), FACS - ABIN610399 : Chang, Xing, Pan, Algeciras-Schimnich, Barnhart, Yaish-Ohad, Peter, Yang: c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. in The EMBO journal 2002 (PubMed)
    Show all 2 references for ABIN610399

  6. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN1108624 : Payne, Kløverpris, Sacha, Brumme, Brumme, Buus, Sims, Hickling, Riddell, Chen, Luzzi, Edwards, Phillips, Prado, Goulder: Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells. in Journal of virology 2010 (PubMed)
    Show all 2 references for ABIN1108624

  7. Human Monoclonal Perforin 1 Primary Antibody for FACS, IF - ABIN222977 : Dulphy, Haas, Busson, Belhadj, Peffault de Latour, Robin, Carmagnat, Loiseau, Tamouza, Scieux, Rabian, Di Santo, Charron, Janin, Socié, Toubert: An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

  8. Human Monoclonal Perforin 1 Primary Antibody for FACS - ABIN1108622 : Cellerai, Perreau, Rozot, Bellutti Enders, Pantaleo, Harari: Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression. in Journal of virology 2010 (PubMed)

  9. Cow (Bovine) Polyclonal Perforin 1 Primary Antibody for WB - ABIN2775294 : Okur, Balta, Akarsu, Oner, Patiroglu, Bay, Sayli, Unal, Gurgey: Clinical and molecular aspects of Turkish familial hemophagocytic lymphohistiocytosis patients with perforin mutations. in Leukemia research 2008 (PubMed)

More Antibodies against Perforin 1 Interaction Partners

Human Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

  1. The decreased expression of perforin in circulating CD3 (show CD3 Antibodies)+CD8 (show CD8A Antibodies)+ positive T cells is an important biomarker of damaged antitumor immunity in advanced lung cancer.

  2. Letter/Case Report: recurrent episodes of macrophage activation syndrome in peripheral spondyloarthritis with monoallelic missense mutations in PRF1.

  3. PRF delivers granulysin (show GNLY Antibodies) and granzymes into parasite infected cells to kill the parasite.

  4. Among SLAMF4 (show CD244 Antibodies)+ cells, the T cell fraction positive for perforin and granzyme B (show Gzmb Antibodies) was higher in those obtained from healthy donors compared to SLE patients.

  5. monoallelic mutations of PRF1 decrease NK-cell cytotoxicity should be considered in individuals presenting with the manifestations of immune deficiency states that impinge on NK-cell cytotoxicity.

  6. Calcific aortic valve disease is characterized by increased expression of granzymes and perforin.

  7. linking PRF1 missense mutations to lymphoma susceptibility and highlighting clinical variability within families. PRF1 mutations should, therefore, be considered as a cause of several diseases disparate to HLH.

  8. PRF1 mutations are associated with hemophagocytic lymphohistiocytosis.

  9. There is no association between gene polymorphisms of PRF1 gene and the susceptibility to hemophagocytic lymphohistiocytosis

  10. A wide heterogeneity was observed in the nature of perforin gene mutations in familial hemophagocytic lymphohistiocytosis patients in India.

Mouse (Murine) Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

  1. Released granzyme B (show Gzmb Antibodies) induces DNA fragmentation in intraepithelial lymphocytes independently of Perforin

  2. serglycin (show SRGN Antibodies) plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin and granzyme B (show Gzmb Antibodies), whereas granzyme A (show GZMA Antibodies) is unaffected

  3. This suggests that LPS alters UNK cell migration and activates cytotoxic granule release.

  4. it is proposed that Ca(2 (show CA2 Antibodies)+) binding at the weakest affinity site triggers changes in the perforin C2 domain that facilitate its interaction with lipid membranes

  5. a lack of perforin and absence of the specific activation of NK cells during acute MCMV infection lead to an unleashed CD8 (show CD8A Antibodies)(+) T cell response that is detrimental for the host.

  6. CD8 (show CD8A Antibodies) T cells are sufficient as a sole perforin-expressing cell type to cause BBB (show ALMS1 Antibodies) disruption in the PIFS (show PROC Antibodies) model.

  7. The rate and proportion of donor lymphoid cell engraftment and expansion of effector memory donor T cells were significantly increased within 5 to 7 days post-bone marrow transplantation in perforin-deficient recipients, compared with wild-type.

  8. Regulatory effects of perforin on glucose tolerance are mechanistically linked to the control of T-cell proliferation and cytokine production in inflamed visceral adipose tissue.

  9. Perforin (and granzyme B (show Gzmb Antibodies))-dependent apoptosis increases postapoptotic necrosis and inflammation in atherosclerosis.

  10. Perforin has a role in atherosclerotic plaque development.

Cow (Bovine) Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

  1. It is a cytotoxic genes in the endometrium and hightly expressed in the peri (show PLIN1 Antibodies)-implantation endometrium.

Perforin 1 (PRF1) Antigen Profile

Antigen Summary

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with Perforin 1 (PRF1)

  • perforin 1 (pore forming protein) (PRF1) antibody
  • perforin (LOC443187) antibody
  • perforin (prf1) antibody
  • perforin 1 (pore forming protein) (Prf1) antibody
  • perforin 1-like (LOC100342396) antibody
  • Cyta antibody
  • FLH2 antibody
  • HPLH2 antibody
  • LOC443187 antibody
  • P1 antibody
  • perforin antibody
  • Pfn antibody
  • PFN1 antibody
  • Pfp antibody
  • Prf-1 antibody
  • prf1 antibody
  • RATCYTA antibody

Protein level used designations for PRF1

perforin 1 (pore forming protein) , perforin-1-like , perforin , perforin-1 , cytolysin , lymphocyte pore forming protein , lymphocyte pore-forming protein , P1 , pore forming protein

450512 Pan troglodytes
100404817 Callithrix jacchus
100473675 Ailuropoda melanoleuca
443187 Ovis aries
100113473 Felis catus
100136143 Oncorhynchus mykiss
5551 Homo sapiens
18646 Mus musculus
50669 Rattus norvegicus
369025 Bos taurus
489030 Canis lupus familiaris
396595 Sus scrofa
100730283 Cavia porcellus
100342396 Oryctolagus cuniculus
427784 Gallus gallus
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