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Browse our TNFSF12 Proteins (TNFSF12)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 12 Proteins (TNFSF12)
On www.antibodies-online.com are 30 Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) Proteins from 11 different suppliers available. Additionally we are shipping TNFSF12 Antibodies (128) and TNFSF12 Kits (31) and many more products for this protein. A total of 198 TNFSF12 products are currently listed.
Synonyms:
Apo3l, Dr3l, Dr3lg, Tweak
list all proteins Gene Name GeneID UniProt
TNFSF12 8742 O43508
TNFSF12 21944 O54907
TNFSF12 360548  

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TNFSF12 Proteins (TNFSF12) by Origin

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Top referenced TNFSF12 Proteins

  1. Human TNFSF12 Protein expressed in Escherichia coli (E. coli) - ABIN2666450 : Bover, Cardó-Vila, Kuniyasu, Sun, Rangel, Takeya, Aggarwal, Arap, Pasqualini: A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 7 references for ABIN2666450

  2. Human TNFSF12 Protein expressed in Escherichia coli (E. coli) - ABIN2667599 : Chicheportiche, Bourdon, Xu, Hsu, Scott, Hession, Garcia, Browning: TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. in The Journal of biological chemistry 1998 (PubMed)
    Show all 6 references for ABIN2667599

  3. Mouse (Murine) TNFSF12 Protein expressed in Human Cells - ABIN2007454 : Campbell, Michaelson, Burkly, Putterman: The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. in Frontiers in bioscience : a journal and virtual library 2004 (PubMed)
    Show all 2 references for ABIN2007454

  4. Rat (Rattus) TNFSF12 Protein expressed in Human Cells - ABIN2009223 : Lynch, Wang, Lund, Chen, Leal, Wiley: TWEAK induces angiogenesis and proliferation of endothelial cells. in The Journal of biological chemistry 1999 (PubMed)
    Show all 2 references for ABIN2009223

  5. Human TNFSF12 Protein expressed in Escherichia coli (E. coli) - ABIN935856 : Han, Mekasha, Ingalls: Fibroblast growth factor-inducible 14 (Fn14) is expressed in the lower genital tract and may play a role in amplifying inflammation during infection. in Journal of reproductive immunology 2010 (PubMed)

More Proteins for TNFSF12 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) interaction partners

  1. The result of transwell assay revealed that TWEAK promoted LX-2 migration. Subsequently, our data testified that the expression and activity of MMP9 (show MMP9 Proteins) was induced by TWEAK in LX-2 cells, which enhanced the migration. Furthermore, our findings showed that TWEAK upregulated the phosphorylation of IkappaBalpha (show NFKBIA Proteins) and p65 (show GORASP1 Proteins) protein to increase MMP9 (show MMP9 Proteins) expression in LX-2 cells.

  2. In this review article, we summarize studies indicating that (i) Fn14 (show TNFRSF12A Proteins) gene expression is low in normal brain tissue but is upregulated in advanced brain cancers and, in particular, in GB tumors ; TWEAK: Fn14 (show TNFRSF12A Proteins) engagement as well as Fn14 (show TNFRSF12A Proteins) overexpression can stimulate glioma cell migration, invasion and resistance to chemotherapeutic agents in vitro.

  3. Findings suggest that TWEAK may contribute to chronic renal changes and renal fibrosis by activating TGF-beta1 (show TGFB1 Proteins) signaling pathway, and phosphorylation of Smad2 (show SMAD2 Proteins) and p38 MAPK (show MAPK14 Proteins) proteins was also involved in this signaling pathway.

  4. The reduced levels of sTWEAK with progression of Hashimoto's Thyroiditis and the significant correlation between the sTWEAK levels and anti-TPO (show THPO Proteins) found in this study suggest that sTWEAK plays an active role in chronic inflammation in the pathogenesis of Hashimoto's Thyroiditis and in the progression of autoimmunity.

  5. Serum TWEAK might be a serologic biomarker candidate that reflects disease activity and renal involvement in patients with SLE

  6. TWEAK/Fn14 (show TNFRSF12A Proteins) activation induces keratinocyte proliferation under psoriatic inflammation

  7. Heart failure with reduced ejection fraction (HF-REF (show THOC4 Proteins)) patients present increased sTWEAK and sCD163 (show CD163 Proteins) levels as well as sTWEAK/sCD163 (show CD163 Proteins) ratio when compared to healthy subjects, however CHF itself appears to be associated with down-regulation of sTWEAK.

  8. The results demonstrated that vitreous fluid from patients with PDR had higher levels of TWEAK and Fn14 than that from T2DM patients without PDR, thus suggesting an important regulatory role of TWEAK/Fn14 signaling in the pathogenesis of PDR.

  9. The main determinant of nitroglycerin-mediated dilation was sTWEAK. In addition, decreased nitroglycerin-mediated dilation was associated with higher systolic blood pressure and pulse pressure. The main determinant of FMD (show FLNA Proteins) was Kt/V. Increased flow-mediated dilation was associated with better dialysis efficiency and high total cholesterol and LDL-cholesterol.

  10. TWEAK levels are slightly elevated in CSF (show CSF2 Proteins) in systemic lupus erythematosus patients compared with non-autoimmune controls, irrespective of the presence of neuropsychiatric disease manifestations. TWEAK levels in serum and CSF (show CSF2 Proteins) do not seem to be a useful biomarker of CNS involvement in SLE.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) interaction partners

  1. Findings suggest that TWEAK may contribute to chronic renal changes and renal fibrosis by activating TGF-beta1 (show TGFB1 Proteins) signaling pathway, and phosphorylation of Smad2 (show SMAD2 Proteins) and p38 MAPK (show MAPK14 Proteins) proteins was also involved in this signaling pathway.

  2. TWEAK/Fn14 (show TNFRSF12A Proteins) signaling represses PGC-1alpha expression during acute kidney injury through activation of canonical NF-kappaB (show NFKB1 Proteins) pathways and epigenetic mechanisms including histone deacetylation on NF-kappaB (show NFKB1 Proteins)-binding sites.

  3. These findings suggest that TWEAK signaling might be an aspect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine -mediated neuropathology and be involved in the overall neurodegenerative pathology of Parkinson's disease

  4. results revealed that TWEAK and Fn14 (show TNFRSF12A Proteins) are expressed by uterine natural killer cells in pregnant mice

  5. studies show that signaling via TWEAK is deleterious to muscle in RNA toxicity and support the demonstrated utility of anti-TWEAK therapeutics.

  6. During ischaemia, soluble CD163 (show CD163 Proteins) functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch (show NOTCH1 Proteins) signalling necessary for myogenic progenitor cell proliferation.

  7. TWEAK/Fn14 (show TNFRSF12A Proteins) interactions play an important role in the pathogenesis of neuropsychiatric lupus by increasing the accumulation of inflammatory cells in the choroid plexus, disrupting blood brain barrier integrity, and increasing neuronal damage

  8. Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis

  9. The results demonstrated that the expression levels of TWEAK and p-p38 MAPK (show MAPK14 Proteins) increased in the periprosthetic interface membrane tissues and the RAW cells stimulated with Ti particles

  10. TWEAK/Fn14 (show TNFRSF12A Proteins) signaling is strongly implicated in the pathogenesis of the cutaneous manifestations in the MRL/lpr (show FAS Proteins) model of spontaneous lupus in mice.

TNFSF12 Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Alternative names and synonyms associated with TNFSF12

  • tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12)
  • tumor necrosis factor (ligand) superfamily, member 12 (Tnfsf12)
  • tumor necrosis factor ligand superfamily member 12 (Tnfsf12)
  • Apo3l protein
  • Dr3l protein
  • Dr3lg protein
  • Tweak protein

Protein level used designations for TNFSF12

APO3 ligand , APO3/DR3 ligand , TNF-related WEAK inducer of apoptosis , tumor necrosis factor ligand superfamily member 12 , tumor necrosis factor superfamily member 12 , TNF-related weak inducer of apoptosis

GENE ID SPECIES
8742 Homo sapiens
100568280 Canis lupus familiaris
21944 Mus musculus
360548 Rattus norvegicus
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