Browse our MMP14 Proteins (MMP14)

Full name:
Matrix Metallopeptidase 14 (Membrane-inserted) Proteins (MMP14)
On www.antibodies-online.com are 27 Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Proteins from 9 different suppliers available. Additionally we are shipping MMP14 Antibodies (263) and MMP14 Kits (28) and many more products for this protein. A total of 332 MMP14 products are currently listed.
Synonyms:
AI325305, MMP-14, MMP-X1, MMP1, MT-MMP, MT-MMP-1, MT-MMP 1, Mt1-mmp, MT1MMP, MTMMP1, sabe
list all proteins Gene Name GeneID UniProt
MMP14 4323 P50281
MMP14 17387 P53690
MMP14 81707 Q10739

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MMP14 Proteins (MMP14) by Origin

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More Proteins for MMP14 Interaction Partners

Human Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. MT1-MMP-expressing cells induced co-cultured non-MT1-MMP-expressing cells.

  2. The mechanism of transition from nondifferentiated to differentiated states in HepaRG cells was studied by proteomics. Two key factors (MMP-14 and OCLN (show OCLN Proteins)) were validated by qRT-PCR and Western blot. Blockade of MMP-14 further demonstrated its important function during tumor cell migration.

  3. Data suggest that phosphorylation of Thr567 in cytoplasmic tail of MT1-MMP (MMP14) influences behavior of both individual ovarian cancer cells and multicellular aggregates; tumor cells expressing MT1-MMP-T567E phosphomimetic mutant exhibit enhanced cell migration and enhanced cell adhesion to peritoneum and other biological surfaces.

  4. MMP-14 Is a novel substrate for matriptase (show ST14 Proteins), which regulates the levels of MMP-14 on the cell surface. High levels of matriptase (show ST14 Proteins) in alpha-1 antitrypsin (show SERPINA1 Proteins) deficiency may contribute to increased extracellular matrix degradation by alveolar macrophages both directly and through MMP-14 activation.

  5. High expression of MMP14 and CDK7 (show CDK7 Proteins) was independent prognostic factors for overall survival in patients with gastric cancer.

  6. only collagen-IV (show COL4 Proteins) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (show SRC Proteins) phosphorylation, p190RhoGAP (show GRLF1 Proteins)-B (also known as ARHGAP5) relocalisation and MT1-MMP (also known as MMP14) cell surface exposure at podosome sites.

  7. This study demonstrates that excessive ECM (show MMRN1 Proteins) degradation mediated by high levels of MT1-MMP is not associated with cell migration and tumourigenesis, while low levels of MT1-MMP promote invasion and vascularization in vivo.

  8. DDR2 (show DDR2 Proteins) mediates collagen-induced activation of MT1-MMP in human fibroblasts

  9. results suggest that the cytoplasmic domain regulates MT1-MMP function in a manner required for cell survival, but is dispensable for cell migration

  10. MMP14 plays an important mechanistic role in NSCLC progression, by supporting cancer invasiveness, promoting collagen degradation, and releasing HB-EGF (show HBEGF Proteins), which accelerates lung tumor progression.

Mouse (Murine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 and MMP15 (show MMP15 Proteins) in regulating mammary gland adipocyte differentiation. Whereas MMP14 promotes the generation of white fat depots crucial for energy storage, MMP15 (show MMP15 Proteins) differentially controls the formation of thermogenic brown fat.

  2. The authors identified the membrane-tethered matrix metalloprotease (show ADAMTS7 PLURAL_@34830@) MT1-MMP as a prominent host-extracellular matrix-remodeling collagenase in influenza infection.

  3. MMP-14 expression in fibroblasts plays a crucial role in collagen remodeling in adult skin and largely contributes to dermal homeostasis underlying its pathogenic role in fibrotic skin disease in a mouse model

  4. MT1-MMP directly cleaves LYVE-1 (show LYVE1 Proteins) on lymphatic endothelial cells to inhibit LYVE-1 (show LYVE1 Proteins)-mediated lymphangiogenic responses and restrains the production of VEGF-C (show VEGFC Proteins).

  5. The authors propose a model for cell-regulated collagen fibril assembly during tendon development in which MMP14 cleaves a molecular bridge tethering collagen fibrils to the plasma membrane of fibripositors.

  6. We demonstrate that MMP-14-mediated signaling in fetal hepatic progenitor cells promotes biliary luminal formation around the portal vein and negatively controls the maturation of hepatocytes.

  7. Results show a reciprocal association between levels of heparanase (show HPSE Proteins) and MMP14, a membrane-bound MMP, shedding light on how branching occurs within developing mammary glands.

  8. MT1-MMP proteolytic activity is required for maintaining cell integrity, loss of MT1-MMP causes cell senescence and nuclear defects.

  9. of the transcripts of tissue inhibitors of matrix metalloproteinases (TIMPs) showed that expression of both TIMP1 (show TIMP1 Proteins) and TIMP2 (show TIMP2 Proteins) correlates negatively with the invasive potential of cells.

  10. Angiotensin II suppresses RECK (show RECK Proteins), but induces matrix metalloproteinases both in vivo and in vitro.

Cow (Bovine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. results suggest that ET-1 (show EDN1 Proteins)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Proteins)-PKCalpha (show PKCa Proteins)-p(38)MAPK (show MAPK1 Proteins) and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Proteins) expression in the cells

  2. Data indicate the involvement of PKC-alpha (show PKCa Proteins) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Proteins) expression by NF-kappaB (show NFKB1 Proteins)-MT1-MMP-dependent and -independent pathway.

  3. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2 (show MMP2 Proteins); MMP-14) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.

  4. MMP-14, MMP-2 (show MMP2 Proteins) and TIMP-2 (show TIMP2 Proteins) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  5. Results describe distinct changes in expression of MMP2 (show MMP2 Proteins), MMP14, and the metallopeptidase (show ECEL1 Proteins) inhibitor TIMP2 (show TIMP2 Proteins) between different phases of the estrous cycle indicating an endocrine regulation.

  6. EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 (show MMP2 Proteins) and MMP-14 suggesting a role in adhesion and fusion of embryo to luminal epithelium.

  7. MT1-MMP seems to act by inducing tissue remodeling in cartilage

  8. sphingosine 1-phosphate is the predominant serum factor essential for MT1-MMP-dependent migration and morphogenic differentiation of vascular endothelial cells

Rabbit Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. MT1-MMP plays a crucial role in RAGE (show AGER Proteins)-activated NADPH oxidase (show NOX1 Proteins)-dependent signaling pathways.

  2. MMP-1 (show MMP1 Proteins) was involved in osteoarthritis development in rabbit ACLT model and the amount of its expression was related with the degree of cartilage degradation.

Pig (Porcine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. Modulation of MT1-MMP activity and microRNA-133a exportation into the myocardial interstitium occurred in the setting of acute myocardial ischemia-reperfusion.

  2. A heterogeneous response in MT1-MMP activity likely contributes to regional dysfunction with ischemia-reperfusion. Subsequent I/R activates a proteolytic cascade within the MI region, contributing to continued adverse remodeling.

  3. PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 (show MMP2 Proteins) as critical events in neointimal hyperplasia after vascular injury.

  4. Induction of endogenous MMP-14 gene and coexpression of SAF-1 (show MAZ Proteins) & MMP-14 in the macrophages present in the atherosclerotic plaque implicate SAF-1 (show MAZ Proteins) as a key regulator of MMP-14 gene induction in macrophage cells.

  5. In an isolated left ventricular myocyte ischemia/reperfusion model, hypoxia induced a >70% increase in MT1-MMP abundance in myocytes. Confocal microscopy revealed MT1-MMP internalization during this time & reemergence to the membrane with reperfusion.

MMP14 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Alternative names and synonyms associated with MMP14

  • matrix metallopeptidase 14 (membrane-inserted) (mmp14)
  • matrix metallopeptidase 14 (membrane-inserted) (MMP14)
  • matrix metallopeptidase 14 (membrane-inserted) (Mmp14)
  • AI325305 protein
  • MMP-14 protein
  • MMP-X1 protein
  • MMP1 protein
  • MT-MMP protein
  • MT-MMP-1 protein
  • MT-MMP 1 protein
  • Mt1-mmp protein
  • MT1MMP protein
  • MTMMP1 protein
  • sabe protein

Protein level used designations for MMP14

matric metalloproteinase 14 , matrix metalloproteinase-14 , membrane type 1 metalloprotease , membrane-type-1 matrix metalloproteinase , MMP-14 , MMP-X1 , MT-MMP 1 , MT1MMP , MTMMP1 , Membrane type 1-MMP , matrix metalloproteinase 14 (membrane-inserted) , membrane-type matrix metalloproteinase 1 , type 1 matrix metalloprotease 14 , matrix metalloproteinase 14 membrane-inserted , matrix metalloproteinase 14, membrane-inserted , membrane type 1-matrix metalloproteinase , MT1-MMP , matrix metalloproteinase 14 preproprotein , matrix metallopeptidase 1 (interstitial collagenase) , matrix metalloproteinase 14 , membrane type 1 metalloproteinase , membrane-type 1 matrix metalloproteinase , membrane type-1 metalloproteinase

GENE ID SPECIES
594950 Xenopus (Silurana) tropicalis
4323 Homo sapiens
17387 Mus musculus
81707 Rattus norvegicus
281915 Bos taurus
100009598 Oryctolagus cuniculus
397471 Sus scrofa
443116 Ovis aries
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