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anti-Human Endothelin-1 Receptor Antibodies:
anti-Rat (Rattus) Endothelin-1 Receptor Antibodies:
anti-Mouse (Murine) Endothelin-1 Receptor Antibodies:
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Mouse (Murine) Polyclonal Endothelin-1 Receptor Primary Antibody for ICC, IF - ABIN269861
Meehan, Delimont, Dufek, Zallocchi, Phillips, Gratton, Cosgrove: Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. in Hearing research 2016
Show all 3 Pubmed References
Fly (Calliphora) Monoclonal Endothelin-1 Receptor Primary Antibody for IF, WB - ABIN968439
Lin, Kaji, Winkel, Ives, Lodish: Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 2 Pubmed References
Fly (Calliphora) Monoclonal Endothelin-1 Receptor Primary Antibody for WB - ABIN968897
Masuda, Miyazaki, Kondoh, Watanabe, Yanagisawa, Masaki, Murakami: Two different forms of endothelin receptors in rat lung. in FEBS letters 1990
Show all 2 Pubmed References
Chicken Polyclonal Endothelin-1 Receptor Primary Antibody for IHC (p), IHC - ABIN443474
Cook, Brais, Qian, Hak, Corrie: Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma. in Journal of clinical pathology 2015
Show all 2 Pubmed References
Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR antagonists might be beneficial for treatment of laminitis in horses.
both endothelin A and endothelin B receptors are involved in the net tonic response to ET-1 (show EDN1 Antibodies) in normal laminar veins.
Data suggest that edn1 (show EDN1 Antibodies)/ednraa (endothelin-1/endothelin-1 (show EDN1 Antibodies) receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (show DNAH8 Antibodies) in zebrafish embryonic skin.
Edn1 (show EDN1 Antibodies) from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
A new role for ednra signaling during early neural crest specification is reported.
ETAR stimulation acted via downstream G-protein Galphaq (show GNAQ Antibodies)/11 and Rho GTPase (show RACGAP1 Antibodies) to suppress the Hippo pathway, thus leading to YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) activation, which was required for ETAR-induced tumorigenesis. Overall, these results indicate a critical role of the YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) axis in ETAR signaling
Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (show ARRB1 Antibodies) (beta-arr1 (show ARRB1 Antibodies)) with Rho guanine nucleotide exchange factor (GEF) 11 (show ARHGEF11 Antibodies) protein (PDZ-RhoGEF (show ARHGEF11 Antibodies)).
In control arteries, ETAR was expressed by vascular smooth muscle cells in the media whereas ETBR (show EDNRB Antibodies) was hardly detected. In giant cell arteritis, both ETAR and ETBR (show EDNRB Antibodies) receptors were expressed by alphaSMA (show ACTA2 Antibodies)-positive cells at the intima-media border. Endothelial cells and inflammatory cells also expressed both ET receptors.
Increased circulating Edn1 (show EDN1 Antibodies) and expression of Ednra in endothelial cells are characteristic of diabetic kidney disease.
Data suggest that TNFalpha (tumor necrosis factor-alpha (show TNF Antibodies)) induces proliferation of airway smooth muscle cells via ET1 (endothelin-1 (show EDN1 Antibodies)), GM-CSF (granulocyte-macrophage colony-stimulating factor (show CSF2 Antibodies)), and IL6 (interleukin 6 (show IL6 Antibodies)) signaling; ET1 (show EDN1 Antibodies) induces cell proliferation via ETAR (endothelin receptor type A); ETBR (endothelin receptor type B (show EDNRB Antibodies)) is up-regulated by TNFalpha (show TNF Antibodies) and appears to mediate ET1 (show EDN1 Antibodies) effects on cell proliferation.
presence of ET-1 (show EDN1 Antibodies) receptors in the chronic thrombus in proximal CTEPH suggests ET-1 (show EDN1 Antibodies) could act not only on the distal vasculopathy in the unobstructed vessels but may also stimulate smooth muscle cell proliferation within chronic clot (show TXNDC17 Antibodies)
Data show that auriculo-condylar syndrome (ACS (show PLA2G15 Antibodies))-associated mutations in G protein subunit alpha i3 (GNAI3 (show GNAI3 Antibodies)) produce dominant-negative Galpha (show SUCLG1 Antibodies)(i3) mutant proteins that couple to endothelin type A receptor (ET(A)R).
Patients with lung fibrosis and patients with high modified Rodnan skin score showed a reduced endothelin 1 (show EDN1 Antibodies) Type A receptor (ETAR)/ETBR (show EDNRB Antibodies) ratio.
High ETAR expression is associated with ovarian carcinoma.
Data show that macitentan interferes with the profibrotic action of transforming growth factor-beta (TGF-beta), blocking the endothelin receptor type A (ET-1 (show EDN1 Antibodies) receptor) portion of the ET-1 (show EDN1 Antibodies)/TGF-beta (show TGFB1 Antibodies) receptor complex.
A MMP-9-cleaved OPN fragment, OPN-32kDa, was responsible for inducing expansion of myeloid-derived suppressor cells, which may contribute to 3LL tumor's evasion of the immune response.
OPN (show SPP1 Antibodies) played a critical role in activating the migration of Mesenchymal stem cells to injured sites and their differentiation into specific skin cell types during skin wound healing.
Findings demonstrate that claudin-low mammary tumor cells rely on OPN (show SPP1 Antibodies) for proliferation, survival and migration as knockdown of OPN (show SPP1 Antibodies) using siRNA inhibited proliferation and migration while increasing apoptosis.
endothelin A receptor activation on mesangial cells is a key event in initiation of Alport glomerular disease in this mouse model.
TSC1 (show TSC1 Antibodies)/TSC2 (show TSC2 Antibodies) complex upregulation of OPN (show SPP1 Antibodies) expression is mediated by transcription factor SOX9 (show SOX9 Antibodies) in an mTOR (show FRAP1 Antibodies)-independent manner. Moreover, ablation of OPN (show SPP1 Antibodies) by deficient TSC1 (show TSC1 Antibodies)/TSC2 (show TSC2 Antibodies) complex contributed to inactivation of AKT (show AKT1 Antibodies) in TSC (show SLC12A3 Antibodies) cells
Intracellular OPN (show SPP1 Antibodies) (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (show SPP1 Antibodies) (sOPN) increase the population size of lymphoid cells. The total effect of OPN (show SPP1 Antibodies) on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis.
this study shows that OPN (show SPP1 Antibodies) promotes sepsis in Pseudomonas aeruginosa-infected mice and potentially blocks B cell-dependent immunity
observed a marked decrease of renal gene expression and urinary excretion of osteopontin (show SPP1 Antibodies) in Npt2a (show SLC34A1 Antibodies)(-/-) mice
data suggest the possibility that Opn (show SPP1 Antibodies) might regulate the homeostasis of intestinal microflora through maintenance of TCRgammadelta+ IELs, possibly by support of IEL survival
OPN (show SPP1 Antibodies) secreted by follicular CD153 (show TNFSF8 Antibodies)(+) senescence-associated T cells in germinal centers (GCs (show UGCG Antibodies)) promotes a continuous supply of intracellular autoantigens via apoptotic cells, thus playing a key role in the progression of the autoreactive GC reaction and leading to pathogenic autoantibody production in lupus-prone mice.
sub-vasomotor concentration of ET-1 (show EDN1 Antibodies) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation
PDE5 (show PDE5A Antibodies) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB (show EDNRB Antibodies) receptor blockade in the presence of PDE5 (show PDE5A Antibodies) inhibition.
Blocking ET(A) and ET(B (show EDNRB Antibodies)) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high intra-abdominal pressure (IAP (show CD47 Antibodies)).
Anti-endothelin receptor A therapy accelerated the reversal of flow-induced pulmonary arterial disease after flow correction.
study suggests a possible role for endothelin-1 (show EDN1 Antibodies)(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Antibodies)) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig
Endothelin-A receptor antagonist alters the expression of vasoactive genes and proinflammatory cytokines during hepatic ischemic/reperfusion.
Report that inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury improved gas exchange and hemodynamics.
ET(A) blockade had no effect on pulmonary vascular resistance at rest or during exercise.
PKC (show FYN Antibodies) and MAPK (show MAPK1 Antibodies) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries
Data suggest that, in Fallopian tubes, endothelins (EDN1 (show EDN1 Antibodies), EDN2 (show EDN2 Antibodies), EDN3 (show EDN3 Antibodies)) and EDN (show RNASE2 Antibodies)-converting enzymes (ECE1 (show ECE1 Antibodies), ECE2 (show ECE2 Antibodies)) are expressed in epithelial cells; EDN (show RNASE2 Antibodies) receptors (EDNRA, EDNRB (show EDNRB Antibodies)) are present in smooth-muscle. Expression of EDN1 (show EDN1 Antibodies), EDN2 (show EDN2 Antibodies), and ECE2 (show ECE2 Antibodies) is highest on day of ovulation. EDN (show RNASE2 Antibodies)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
Differential cell-specific and spatiotemporal expression of the EDN1 (show EDN1 Antibodies) system and NOS (show NOS Antibodies) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Elevated local expression of ET-1 (show EDN1 Antibodies) and Ednra/Ednrb (show EDNRB Antibodies) during the peri (show PLIN1 Antibodies)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
, endothelin receptor A
, endothelin receptor type A
, endothelin type-A receptor 2
, Endothelin-1 receptor type A
, endothelin receptor type A a
, G protein-coupled receptor
, endothelin receptor subtype A
, endothelin-1-specific receptor
, endothelin A receptor
, G-protein coupled receptor 10
, 44 kDa bone phosphoprotein
, bone sialoprotein 1
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein