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Replacing murine Mc3r with and double-mutant (C17A+G241A) human MC3R showed greater weight and fat mass, increased energy intake and feeding efficiency.
MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.
The minimum promoter region required for Mc3r expression has been identified, along with two binding sites for AP-1 (show JUN Proteins) and ATF4 (show ATF4 Proteins) and in the 5' upstream-flanking region of Mc3r that are essential for Mc3r expression.
3' RACE experiments using hypothalamic RNA indicated the 3' UTR terminates approximately 1286 bases after the translational stop codon, with a previously unknown 787 base splice between consensus splice donor and acceptor sites.
These data reveal novel protective properties of endogenous MC3 on periodontal status in health and disease
Data suggest that Mc3r (not Mc4r (show MC4R Proteins)) is expressed in 1/3 of dopaminergic neurons in ventral tegmental area (VTA); global deletion of Mc3r in knockout mice increases VTA dopamine by 42% and decreases sucrose intake/preference in female (not male) mice.
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin (show GHRL Proteins) and melanocortin-3 receptors.
data suggest that the melanocortin-3 receptor is involved in the control of energy balance and the expression of rhythms anticipating nutrient intake.
MC(3) plays a subtle role in the regulation of food intake
Compared with WT, MC4R (show MC4R Proteins)-/- showed no activation in area postrema but showed normal activation in paraventricular hypothalamus, whereas MC3R-/- showed reduced activation in PVN but not in AP.
There is no evidence of any association between MC3R variations and obesity.
melanocortin receptors MC2R, MC3R and MC5R (show MC5R Proteins) are most abundantly expressed in glandular epithelium of the endometrium
the DPLIY motif and helix 8 was important for MC3R activation and signal transduction. The data led to a better understanding of the structure-function relationship of MC3R.
novel data about the structure-function relationship of MC3R, identifying residues important for receptor function; some studied mutations exhibited biased signaling, preferentially activating one intracellular signaling pathway.
propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1 (show CYP24A1 Proteins), and GRM8 (show GRM8 Proteins)).
The cytoplasmic end of transmembrane domain 3 and the intracellular loop 2 were critical for MC3R function.
MC3R polymorphism is marginally associated in the development of pulmonary tuberculosis in Korean population.
MC3R is a 2-exon gene that requires a 5' UTR for translation, localization, and potential interaction with MRAP2
3' RACE experiments using MC3R transcript indicated the 3' UTR terminates approximately 115-160 bases after the translational stop codon.
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.
melanocortin receptor 3
, melanocortin-3 receptor
, obesity quantitative trait locus