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anti-Mouse (Murine) Prostacyclin Receptor Antibodies:
anti-Human Prostacyclin Receptor Antibodies:
anti-Rat (Rattus) Prostacyclin Receptor Antibodies:
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Human Polyclonal Prostacyclin Receptor Primary Antibody for WB - ABIN2801905
Boie, Rushmore, Darmon-Goodwin, Grygorczyk, Slipetz, Metters, Abramovitz: Cloning and expression of a cDNA for the human prostanoid IP receptor. in The Journal of biological chemistry 1994
Show all 4 Pubmed References
Human Polyclonal Prostacyclin Receptor Primary Antibody for IHC (p) - ABIN4348406
Li, Hoxha, Lama, Dinh, Vo, Dauwalder: The hector G-protein coupled receptor is required in a subset of fruitless neurons for male courtship behavior. in PLoS ONE 2011
results provide evidence that PGI2/IP signaling suppresses the STAT6 (show STAT6 Antibodies)-independent pathway of allergic airway inflammation
Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (Ptgir) is involved in insulin (show INS Antibodies) secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin (show NPHS1 Antibodies).
Deletion of the I prostanoid receptor had no effect on the attenuation of atherogenesis by mPGES-1 (show PTGES Antibodies) deletion in the low-density lipoprotein receptor (show LDLR Antibodies) knockout mice.
Prostacyclin promotes the up-regulation of Nox4 (show NOX4 Antibodies) in endothelial cells, which opens up a novel strategy that protects and enhances endothelial cell functions in cardiovascular disease, such as repair after myocardial infarction or other ischemic conditions.
Its signaling increase cAMP concentration, which prototes sysnesis of HGF (show HGF Antibodies), causing angiogenesis.
an essential role of the COX-2 (show COX2 Antibodies)/PGI2 receptor axis in the cardioprotection afforded by the late ischemic preconditioning
findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target
PGI2-induced PPAR delta (show PPARD Antibodies) activation accelerates blastocyst hatching in mice
For the first time these results show that activation of prostaglandin I2 receptor can attenuate damage following cerebral ischemia.
identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (show CD4 Antibodies)(+) Th2 cells into the inflammatory site
these studies are not only the first to identify alpha4 helix of Rab11a as a protein binding domain on the GTPase but also reveal novel mechanistic insights into the intracellular trafficking of the human prostacyclin receptor (hIP), and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms.
role of IP-PPARdelta (show PPARD Antibodies) signal transduction pathway in the production of sAPPalpha in cerebral microvasculature.
Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (PTGIR) is involved in insulin (show INS Antibodies) secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin (show NPHS1 Antibodies).
The human prostacyclin receptor gene is under the transcriptional regulation of dihydrotestosterone, where this regulation is further influenced by serum-cholesterol levels.
these findings suggest that reduced IPR expression in DM2 (show CNBP Antibodies) platelets may contribute to platelet hyperactivity in humans with type 2 diabetes.
Prostaglandin I2- Prostaglandin I2 receptor signaling regulates human Th17 and Treg cell differentiation.
these data provide critical insights into the transcriptional regulation of the human prostacyclin receptor gene within the vasculature, including during megakaryocytic differentiation
IP receptor heteridimerization with thromboxane receptor (show TBXA2R Antibodies) facilitates receptor trafficking to membrane lipid rafts.
Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3 (show STAT3 Antibodies)-dependent
IKEPP (show PDZD3 Antibodies) was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
, PGI2 receptor
, prostacyclin receptor
, prostaglandin I2 receptor
, prostanoid IP receptor
, prostaglandin I receptor (IP)