Browse our GCKR Proteins (GCKR)

Full name:
Glucokinase (Hexokinase 4) Regulator Proteins (GCKR)
On are 17 Glucokinase (Hexokinase 4) Regulator (GCKR) Proteins from 5 different suppliers available. Additionally we are shipping GCKR Antibodies (87) and GCKR Kits (24) and many more products for this protein. A total of 135 GCKR products are currently listed.
list all proteins Gene Name GeneID UniProt
GCKR 2646 Q14397
GCKR 25658 Q07071
GCKR 231103 Q91X44

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GCKR Proteins (GCKR) by Origin

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More Proteins for GCKR Interaction Partners

Human Glucokinase (Hexokinase 4) Regulator (GCKR) interaction partners

  1. Three loci showed robust, replicating association with circulating FXI (show F11 Proteins) levels: KNG1 (show KNG1 Proteins) (rs710446, P-value = 2.07 x 10-302), F11 (show F11 Proteins) (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI (show F11 Proteins) regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (show F3 Proteins) time

  2. GCKR association with adiposity and the risk of the nonalcoholic fatty liver disease

  3. The existence of a liver-specific FOXA2 (show FOXA2 Proteins)-regulated transcriptional enhancer at an intronic T2D locus represented by rs780094, rs780095, and rs780096 SNPs that increases GCKR expression is demonstrated.

  4. GCKR Leu446 may influence FGF21 (show FGF21 Proteins) expression via its ability to increase glucokinase (GCK (show GCK Proteins)) activity. This can lead to enhanced FGF21 (show FGF21 Proteins) expression via elevated fatty acid synthesis, consequent to the inhibition of carnitine/palmitoyl-transferase by malonyl-CoA, and via increased glucose-6-phosphate-mediated activation of the carbohydrate response element binding protein (show MLXIPL Proteins), known to regulate FGF21 (show FGF21 Proteins) gene expression.

  5. Data suggest that hepatic glucokinase (show GCK Proteins) activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2 (show PFKFB3 Proteins)/FBP2 (show KHSRP Proteins)); changes in glucokinase (show GCK Proteins) expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]

  6. The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1 (show LAMC1 Proteins)) locus showed suggestive association with disease.

  7. Among Mexicans, the PNPLA3 (show PNPLA3 Proteins) (rs738409), LYPLAL1 (show LYPLAL1 Proteins) (rs12137855), PPP1R3B (show PPP1R3B Proteins) (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults.

  8. The present study explored the association between a common variant of the glucokinase regulator (GCKR) gene and metabolic syndrome and its related traits in Taiwanese adolescents

  9. This study shows that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fat content was related to GCKR rs1260326 polymorphism

  10. Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD

Xenopus laevis Glucokinase (Hexokinase 4) Regulator (GCKR) interaction partners

  1. Glucokinase regulatory protein binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.

Mouse (Murine) Glucokinase (Hexokinase 4) Regulator (GCKR) interaction partners

  1. Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies.

  2. Germinal center kinase-related (show MAP4K5 Proteins) enzyme (GCKR) facilitates both canonical and noncanonical Wnt (show WNT2 Proteins) signaling in B lymphocytes.

GCKR Protein Profile

Protein Summary

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).

Alternative names and synonyms associated with GCKR

  • glucokinase (hexokinase 4) regulator (GCKR)
  • glucokinase (hexokinase 4) regulator (Gckr)
  • glucokinase regulator (MGC68583)
  • glucokinase regulatory protein (Gckr)
  • glucokinase regulatory protein-like (LOC100350724)
  • mitogen-activated protein kinase kinase kinase kinase 5 (Map4k5)
  • 4432415E19Rik protein
  • FGQTL5 protein
  • GCKR protein
  • GKRP protein
  • GLRE protein
  • KHS protein
  • MAPKKKK5 protein

Protein level used designations for GCKR

glucokinase regulatory protein , glucokinase regulator , MAPK/ERK kinase kinase kinase 5 , MEK kinase kinase 5 , MEKKK 5

100071177 Equus caballus
2646 Homo sapiens
25658 Rattus norvegicus
100728544 Cavia porcellus
100625192 Sus scrofa
475705 Canis lupus familiaris
398839 Xenopus laevis
231103 Mus musculus
100350724 Oryctolagus cuniculus
399510 Mus musculus
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