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NUMB is necessary for establishing polarity in coelomic epithelium cells.
investigations revealed that NUMB and NUMBL (show NUMBL ELISA Kits) interacted with small GTPase (show RACGAP1 ELISA Kits) Rab7 (show RAB7A ELISA Kits) to transition ERBB2 (show ERBB2 ELISA Kits) from early to late endosome for degradation.
These findings highlight the importance of Numb and Numbl (show NUMBL ELISA Kits) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis
RBM4 (show RBM4 ELISA Kits) depletion reduced the expression of the proneural gene Mash1 (show ASCL1 ELISA Kits), and such reduction was reversed by an RBM4 (show RBM4 ELISA Kits)-induced Numb isoform containing exon 3 but lacking exon 9. RBM4 (show RBM4 ELISA Kits) was also essential for neurite outgrowth from cortical neurons in vitro. Neurite outgrowth defects of RBM4 (show RBM4 ELISA Kits)-depleted neurons were rescued by RBM4 (show RBM4 ELISA Kits)-induced exon 9-lacking Numb isoforms. RBM4 (show RBM4 ELISA Kits) modulates exon selection of Numb.
role in the mediation of TCR degradation
miR (show MLXIP ELISA Kits)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (show NOTCH1 ELISA Kits) to separate stem and non-stem cell fates robustly.
Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (show TLR4 ELISA Kits).
Loss of Numb induces a p53 (show TP53 ELISA Kits)-dependent senescence following skeletal muscle injury.
Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (show GRM1 ELISA Kits).
we observed a glial reaction and an activity-dependent modification of Shh (show SHH ELISA Kits), Noggin (show NOG ELISA Kits), and Numb proteins. we found that Shh (show SHH ELISA Kits) and Noggin (show NOG ELISA Kits) could affect motor performance and that these proteins could be associated with both TDP-43 (show TARDBP ELISA Kits) and Numb
Using patient-derived xenografts, the study shows that expansion of the cancer stem cells pool, due to altered self-renewing divisions, is also a feature of Numb-deficient human breast cancers .
Numb binds to another docking regulator, Mon1b, and is required for the recruitment of cytosolic Mon1b to the early endosomes membrane.
Low NUMB expression is associated with pancreatic cancer.
Together, our findings revealed a novel function of Numb and its likely mechanism in regulation of autophagy events.
investigations revealed that NUMB and NUMBL (show NUMBL ELISA Kits) interacted with small GTPase (show RACGAP1 ELISA Kits) Rab7 (show RAB7B ELISA Kits) to transition ERBB2 (show ERBB2 ELISA Kits) from early to late endosome for degradation.
Our evidence supports a mechanism by which Numb AS is regulated in response to oncogenic signaling pathways, and contributes to activation of downstream pathways to promote tumorigenesis.
Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 (show SLC1A1 ELISA Kits) through binding the YxNxxF (where x stands for any amino acid) motif.
HBeAg and its precursors promote HDM2-mediated degradation and impair transcriptional activity of p53 (show TP53 ELISA Kits) by interacting with NUMB, consequently contributing to hepatocellular carcinoma development.
High expression of Numb is associated with radiation resistance in pancreatic cancer.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
protein numb homolog
, numb gene homolog