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NUMB is necessary for establishing polarity in coelomic epithelium cells.
investigations revealed that NUMB and NUMBL (show NUMBL Proteins) interacted with small GTPase (show RACGAP1 Proteins) Rab7 (show RAB7A Proteins) to transition ERBB2 (show ERBB2 Proteins) from early to late endosome for degradation.
These findings highlight the importance of Numb and Numbl (show NUMBL Proteins) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis
RBM4 (show RBM4 Proteins) depletion reduced the expression of the proneural gene Mash1 (show ASCL1 Proteins), and such reduction was reversed by an RBM4 (show RBM4 Proteins)-induced Numb isoform containing exon 3 but lacking exon 9. RBM4 (show RBM4 Proteins) was also essential for neurite outgrowth from cortical neurons in vitro. Neurite outgrowth defects of RBM4 (show RBM4 Proteins)-depleted neurons were rescued by RBM4 (show RBM4 Proteins)-induced exon 9-lacking Numb isoforms. RBM4 (show RBM4 Proteins) modulates exon selection of Numb.
role in the mediation of TCR degradation
miR (show MLXIP Proteins)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (show NOTCH1 Proteins) to separate stem and non-stem cell fates robustly.
Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (show TLR4 Proteins).
Loss of Numb induces a p53 (show TP53 Proteins)-dependent senescence following skeletal muscle injury.
Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (show GRM1 Proteins).
we observed a glial reaction and an activity-dependent modification of Shh (show SHH Proteins), Noggin (show NOG Proteins), and Numb proteins. we found that Shh (show SHH Proteins) and Noggin (show NOG Proteins) could affect motor performance and that these proteins could be associated with both TDP-43 (show TARDBP Proteins) and Numb
Using patient-derived xenografts, the study shows that expansion of the cancer stem cells pool, due to altered self-renewing divisions, is also a feature of Numb-deficient human breast cancers .
Numb binds to another docking regulator, Mon1b, and is required for the recruitment of cytosolic Mon1b to the early endosomes membrane.
Low NUMB expression is associated with pancreatic cancer.
Together, our findings revealed a novel function of Numb and its likely mechanism in regulation of autophagy events.
investigations revealed that NUMB and NUMBL (show NUMBL Proteins) interacted with small GTPase (show RACGAP1 Proteins) Rab7 (show RAB7B Proteins) to transition ERBB2 (show ERBB2 Proteins) from early to late endosome for degradation.
Our evidence supports a mechanism by which Numb AS is regulated in response to oncogenic signaling pathways, and contributes to activation of downstream pathways to promote tumorigenesis.
Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 (show SLC1A1 Proteins) through binding the YxNxxF (where x stands for any amino acid) motif.
HBeAg and its precursors promote HDM2-mediated degradation and impair transcriptional activity of p53 (show TP53 Proteins) by interacting with NUMB, consequently contributing to hepatocellular carcinoma development.
High expression of Numb is associated with radiation resistance in pancreatic cancer.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
protein numb homolog
, numb gene homolog