Browse our anti-CDK6 (CDK6) Antibodies

Full name:
anti-Cyclin-Dependent Kinase 6 Antibodies (CDK6)
On www.antibodies-online.com are 256 Cyclin-Dependent Kinase 6 (CDK6) Antibodies from 26 different suppliers available. Additionally we are shipping CDK6 Kits (13) and CDK6 Proteins (13) and many more products for this protein. A total of 297 CDK6 products are currently listed.
Synonyms:
5830411I20, AI504062, CDK6, Crk2, PLSTIRE
list all antibodies Gene Name GeneID UniProt
CDK6 1021 Q00534
CDK6 12571 Q64261
CDK6 114483  

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Top referenced anti-CDK6 Antibodies

  1. Human Monoclonal CDK6 Primary Antibody for IF, WB - ABIN393888 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for 393888

  2. Human Polyclonal CDK6 Primary Antibody for IF (p), IHC (p) - ABIN670236 : Yang, Wang, Hui, Li, Jiang: SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/?-catenin pathway. in Tumour biology 2015 (PubMed)
    Show all 4 references for 670236

  3. Human Polyclonal CDK6 Primary Antibody for IF, IHC (p) - ABIN319289 : Flores-Rozas, Kelman, Dean, Pan, Harper, Elledge, ODonnell, Hurwitz: Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 3 references for 319289

  4. Human Polyclonal CDK6 Primary Antibody for IHC (p) - ABIN319413 : Pestell, Albanese, Reutens, Segall, Lee, Arnold: The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. in Endocrine reviews 1999 (PubMed)
    Show all 3 references for 319413

  5. Human Polyclonal CDK6 Primary Antibody for IF, IHC (p) - ABIN401596 : Hirai, Roussel, Kato, Ashmun, Sherr: Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. in Molecular and cellular biology 1995 (PubMed)
    Show all 3 references for 401596

  6. Human Polyclonal CDK6 Primary Antibody for IF, IHC (p) - ABIN319411 : Lukas, Bartkova, Bartek: Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. in Molecular and cellular biology 1997 (PubMed)
    Show all 3 references for 319411

  7. Human Monoclonal CDK6 Primary Antibody for IF, WB - ABIN1106651 : Lien, Lin, Huang, Chang, Hsu: Expression of cyclin-dependent kinase 6 (cdk6) and frequent loss of CD44 in nasal-nasopharyngeal NK/T-cell lymphomas: comparison with CD56-negative peripheral T-cell lymphomas. in Laboratory investigation; a journal of technical methods and pathology 2000 (PubMed)
    Show all 3 references for 1106651

  8. Human Monoclonal CDK6 Primary Antibody for IP, WB - ABIN488121 : Tsubari, Taipale, Tiihonen, Keski-Oja, Laiho: Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity. in Molecular and cellular biology 1999 (PubMed)
    Show all 2 references for 488121

  9. Human Monoclonal CDK6 Primary Antibody for IHC (fro), IP - ABIN119189 : Elledge: Cell cycle checkpoints: preventing an identity crisis. in Science (New York, N.Y.) 1997 (PubMed)

  10. Cow (Bovine) Polyclonal CDK6 Primary Antibody for WB - ABIN2792149 : Mendrzyk, Radlwimmer, Joos, Kokocinski, Benner, Stange, Neben, Fiegler, Carter, Reifenberger, Korshunov, Lichter: Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 (PubMed)

More Antibodies against CDK6 Interaction Partners

Human Cyclin-Dependent Kinase 6 (CDK6) interaction partners

  1. Describe a regulatory loop miR (show MLXIP Antibodies)-218-CDK6/CyclinD1-E2F1 (show E2F1 Antibodies) whose disruption may contribute to cell cycle progression in gastric cancer.

  2. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (show E2F1 Antibodies) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (show CDK4 Antibodies) inhibitors in breast cancer for the development of more effective combination therapies.

  3. The deletion of CBX3 (show CBX3 Antibodies) directly enforces the expression of CDK6 and p21 (show CDKN1A Antibodies).

  4. Amplification of the G1-S regulatory genes, CCNE1, CCND1 and CdK6, represent an early event, which precedes ERBB2, EGFR, or KRAS amplification in gastric adenocarcinoma.

  5. CDK6-mediated suppression of CD25 (show IL2RA Antibodies) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Antibodies)

  6. CDK6 overexpression is associated with cancer.

  7. High CDK6 expression is associated with Melanoma.

  8. Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein

  9. Our study proved that the CDK6 gene is a target of miR (show MLXIP Antibodies)-637, and demonstrated the regulatory association between miR (show MLXIP Antibodies)-637 and CDK6

  10. we verified that miR (show MLXIP Antibodies)-892b regulates the p19ARF (show CDKN2A Antibodies)/cyclin D1 (show CCND1 Antibodies)/CDK6 and Sp-1 (show PSG1 Antibodies)/MMP-9 (show MMP9 Antibodies) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.

Mouse (Murine) Cyclin-Dependent Kinase 6 (CDK6) interaction partners

  1. PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6 (show CDK4 Antibodies)), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 (show CDK4 Antibodies) inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.

  2. CDK6-mediated suppression of CD25 (show IL2RA Antibodies) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Antibodies). . Pharmacologic inhibition of CDK6 kinase induces CD25 (show IL2RA Antibodies) and RUNX1 (show RUNX1 Antibodies) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.

  3. Fbxo7 (show FBXO7 Antibodies)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 (show CDKN1B Antibodies) levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Antibodies) at different stages in T-cell development.

  4. Taken together, our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression.

  5. Data show that E11/glycoprotein 38 (show PDPN Antibodies)(GP38 (show PDPN Antibodies)) was up-regulated upon SEMA3A (show SEMA3A Antibodies) stimulation, and cyclin-dependent kinase 6 (CDK6) was down-regulated in a time-dependent manner.

  6. Notch3 (show NOTCH3 Antibodies) transcription and growth of lymphoma cells was dependent on CDK6.

  7. CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (show EGR1 Antibodies) in hematopoietic and leukemic stem cell activation

  8. Cdk4 (show CDK4 Antibodies) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 (show CDKN2A Antibodies) proteins away from Cdk4 (show CDK4 Antibodies).

  9. Cdk6/Ccnd1 (show CCND1 Antibodies) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (show PGR Antibodies); the chondrocytes then undergo p53 (show TP53 Antibodies)-dependent apoptosis

  10. p107 (show RBL1 Antibodies) retinoblastoma protein is regulated by Cdk6/Ccnd1 (show CCND1 Antibodies) in growth plates.

Cow (Bovine) Cyclin-Dependent Kinase 6 (CDK6) interaction partners

  1. the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth

CDK6 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with CDK6

  • cyclin-dependent kinase 6 (CDK6) antibody
  • cyclin-dependent kinase 6 (Cdk6) antibody
  • 5830411I20 antibody
  • AI504062 antibody
  • CDK6 antibody
  • Crk2 antibody
  • PLSTIRE antibody

Protein level used designations for CDK6

cyclin-dependent kinase 6 , cell division protein kinase 6-like , cell division protein kinase 6 , serine/threonine-protein kinase PLSTIRE , CR2 protein kinase

GENE ID SPECIES
746968 Pan troglodytes
100454924 Pongo abelii
1021 Homo sapiens
12571 Mus musculus
114483 Rattus norvegicus
609920 Canis lupus familiaris
511754 Bos taurus
420558 Gallus gallus
100518921 Sus scrofa
100009040 Oryctolagus cuniculus
100061625 Equus caballus
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