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Browse our CDKN1A Proteins (CDKN1A)

Full name:
Cyclin-Dependent Kinase Inhibitor 1A Proteins (CDKN1A)
On www.antibodies-online.com are 3 Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) Proteins from 2 different suppliers available. Additionally we are shipping CDKN1A Kits (8) and CDKN1A Antibodies (4) and many more products for this protein. A total of 15 CDKN1A products are currently listed.
Synonyms:
CAP20, CDKI, Cdkn1, CIP1, MDA-6, mda6, P21, p21Cip1, p21WAF, SDI1, Waf1
list all proteins Gene Name GeneID UniProt
CDKN1A 1026 P38936
Mouse CDKN1A CDKN1A 12575 P39689
CDKN1A    

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CDKN1A Proteins (CDKN1A) by Origin

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More Proteins for CDKN1A Interaction Partners

Human Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) interaction partners

  1. These results show that ASPL (show ASPSCR1 Proteins)-TFE3 (show TFE3 Proteins) regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression.

  2. our study provides evidence that up-regulation of p21 is mainly responsible for the suppressive effect of miR (show MLXIP Proteins)-1180-5p on human bladder cancer cells and miR (show MLXIP Proteins)-1180-5p can significantly inhibit tumorigenicity in vivo.

  3. Low CIP1 expression is associated with renal cell carcinoma (show MOK Proteins).

  4. RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 (show TP53 Proteins) target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer

  5. These findings suggest that normal p53 (show TP53 Proteins) function is crucial in ATM (show ATM Proteins)/p53 (show TP53 Proteins)/p21 pathway activated by LDIR. The p53 (show TP53 Proteins) status is the most probable reason leading to differential LDIR biological activities between breast tumor cells and normal breast cells

  6. PPARg (show PPARG Proteins) signaling pathway may involve in the proliferation inhibition of evodiamine on K562 cells via inhibiting cylcin D1 and stimulating of p21.

  7. CDKN1A expression is induced by miR (show MLXIP Proteins)-3619-5p by directly targeting the putative site in the promoter in prostate cancer cells.

  8. miR (show MLXIP Proteins)-92a, which is upregulated in cervical cancer, plays an oncogenic role in cervical cancer cell proliferation by directly targeting p21 and thus promoting cell cycle progression.

  9. KLF6 (show KLF6 Proteins) acts as a tumor suppressor in CMM cells and miR (show MLXIP Proteins)-4262 promotes the proliferation of CMM cells through KLF6 (show KLF6 Proteins)-mediated EGFR (show EGFR Proteins) inactivation and p21 upregulation.

  10. the combination of a proteasomal inhibitor and dimethylfumarate superinduces p21 expression in human dermal lymphendothelial cells

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) interaction partners

  1. this study shows that p21 is upregulated in T effector cells but not natural regulatory T cells after treatment with azacitidine, which protects from graft-versus-host Disease

  2. lincRNA-p21 overexpression dramatically inhibited acetylation of H3 and H4 at the Thy-1 (show THY1 Proteins) promoter and Thy-1 (show THY1 Proteins) expression levels in HLF1 (show HLF Proteins) cells. Finally, lincRNA-p21 interference rescued LPS (show TLR4 Proteins)-induced increase of lung and BAL collagen contents. LincRNA-p21 could lead to pulmonary fibrosis in ARDS by inhibition of the expression of Thy-1 (show THY1 Proteins).

  3. p21 upregulation in hair follicle stem cells is associated with telogen retention in aged mice

  4. MiR-17-92 functions as a hepatocyte proliferation stimulator and acts in an estrogen-dependent manner. The loss of this miRNA results in increases in p21 and Pten expression and therefore impairs liver regeneration in female mice.

  5. we observed that miR (show MLXIP Proteins)-378 modulates the oscillation amplitudes of Cdkn1a in the control of cell cycle and Por (show POR Proteins) in the regulation of oxidation reduction by forming partnership with different circadian transcription factors

  6. The findings define PRMT7 (show PRMT7 Proteins) as a regulator of the DNMT3b (show DNMT3B Proteins)/p21 axis required to maintain muscle stem cell regenerative capacity.

  7. Dynamics of CDKN1A in single cells has been defined defined by an endogenous fluorescent tagging.

  8. Ablation of p21Cip1 in the Cdk4 (show CDK4 Proteins) R24C background accelerates mesenchymal tumor development in mice.

  9. The lack of functional Waf1 is indispensable for maintaining self-renewal and pluripotency of embryonic stem cells.

  10. p27(Kip1 (show CDKN1B Proteins)) and p21(Cip1) are insufficient for the proliferative inhibition of smooth muscle cells cultured in type 1 collagen.

CDKN1A Protein Profile

Protein Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Alternative names and synonyms associated with CDKN1A

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A)
  • cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a)
  • CAP20 protein
  • CDKI protein
  • Cdkn1 protein
  • CIP1 protein
  • MDA-6 protein
  • mda6 protein
  • P21 protein
  • p21Cip1 protein
  • p21WAF protein
  • SDI1 protein
  • Waf1 protein

Protein level used designations for CDKN1A

CDK-interacting protein 1 , CDK-interaction protein 1 , DNA synthesis inhibitor , cyclin-dependent kinase inhibitor 1 , melanoma differentiation associated protein 6 , wild-type p53-activated fragment 1 , melanoma differentiation-associated protein , p21

GENE ID SPECIES
1026 Homo sapiens
12575 Mus musculus
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