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Browse our CDKN1A Proteins (CDKN1A)

Full name:
Cyclin-Dependent Kinase Inhibitor 1A Proteins (CDKN1A)
On are 2 Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) Proteins from 2 different suppliers available. Additionally we are shipping CDKN1A Kits (6) and CDKN1A Antibodies (4) and many more products for this protein. A total of 12 CDKN1A products are currently listed.
CAP20, CDKI, Cdkn1, CIP1, MDA-6, mda6, P21, p21Cip1, p21WAF, SDI1, Waf1
list all proteins Gene Name GeneID UniProt
CDKN1A 1026 P38936
Mouse CDKN1A CDKN1A 12575 P39689

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CDKN1A Proteins (CDKN1A) by Origin

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More Proteins for CDKN1A Interaction Partners

Human Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) interaction partners

  1. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Proteins) pathways and p21 Cip1 expression.

  2. Data suggest that HOXA-AS2 (show ARSA Proteins) could be an oncogene (show RAB1A Proteins) for GC partly through suppressing P21, PLK3 (show PLK3 Proteins), and DDIT3 (show DDIT3 Proteins) expression.

  3. Findings suggest that the regulation of c-Myc (show MYC Proteins) in breast cancer cells is dependent on the molecular subtype, and that beta-catenin (show CTNNB1 Proteins)-mediated regulation of c-Myc (show MYC Proteins) and p21 may control the balance of cell death and proliferation in breast cancer.

  4. These findings point to (i) the relevance of CS-related mechanisms in Hodgkin lymphoma , and to (ii) the prognostic value of a simple, reproducible, and low-cost immunohistochemical evaluation of p16(INK4a) and p21(CIP1/WAF1) expression.

  5. Plk3 (show PLK3 Proteins) is involved in the inhibition of cell proliferation and tumorigenesis, which may occur via interactions with p21.

  6. Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (show CDK2 Proteins).

  7. prolactin (show PRL Proteins) activation of Stat5 (show STAT5A Proteins) results in the formation of a complex between phospho-Stat5 (show STAT5A Proteins) and BRCA1. Formation of this complex does not interfere with nuclear translocation or binding of BRCA1 to the p21 promoter

  8. the meta-analysis suggested that, in the p21 Ser31Arg polymorphism, Ser (show SIGLEC1 Proteins)-allele and Ser/Ser (show SIGLEC1 Proteins) genotype might be risk factors for gastrointestinal tract tumor in Asian populations

  9. Data showed that miR (show MLXIP Proteins)-423 was up-regulated in colorectal cancer (CRC (show CALR Proteins)) tissues promoting cell proliferation. Cip1 mediated the function of miR (show MLXIP Proteins)-423, and its overexpression reversed the augmented effect of miR (show MLXIP Proteins)-423 on cell proliferation.

  10. This case-control study was designed to analyse the association Single nucleotide polymorphisms (SNPs) of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270 and retinoblastoma (RB) in a Chinese Han population.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) interaction partners

  1. Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (show CDK2 Proteins).

  2. TFAP2C (show TFAP2C Proteins) in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK (show MAPK1 Proteins) pathway, further supporting differentiation of glycogen (show GYS1 Proteins) cells by activating the AKT (show AKT1 Proteins) pathway

  3. Interaction between ASPM and the Cdk2 (show CDK2 Proteins)/Cyclin E (show CCNE1 Proteins) complex regulated the Cyclin (show PCNA Proteins) activity by modulating its ubiquitination and localization into the nucleus.

  4. we present evidence that VPA administration to mice increases hippocampal p21 expression, accompanied by DNA demethylation at the distal CpG island.

  5. LKB1 (show STK11 Proteins) mediates CDKN1A degradation in response to ultraviolet DNA damage.

  6. At high glucose concentrations in vitro, AdipoR1 (show ADIPOR1 Proteins) regulated the survival of neural stem cells through the p53 (show TP53 Proteins)/p21 pathway and the proliferation- and differentiation-related factors of neural stem cells via TLX (show NR2E1 Proteins).

  7. Phosphorylation of p53 (show TP53 Proteins) by LRRK2 (show LRRK2 Proteins) induces p21(WAF1/CIP1) expression and apoptosis.

  8. AMP-18 (show GKN1 Proteins) appears to act through PI3K/AKT (show AKT1 Proteins) pathways to increase p21 phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha (show TNF Proteins).

  9. Intense P21 expression observed in basal and supra-basal layers facing future dental papilla cells, weakly expressed in other basal cells. P21 is exclusively found in the IEE, supra-IEE and several dental papilla cells in mice.

  10. Deficiency of CDKN1A or both CDKN1A and CDKN1B (show CDKN1B Proteins) affects the pubertal development of mouse Leydig cells.

CDKN1A Protein Profile

Protein Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Alternative names and synonyms associated with CDKN1A

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A)
  • cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a)
  • CAP20 protein
  • CDKI protein
  • Cdkn1 protein
  • CIP1 protein
  • MDA-6 protein
  • mda6 protein
  • P21 protein
  • p21Cip1 protein
  • p21WAF protein
  • SDI1 protein
  • Waf1 protein

Protein level used designations for CDKN1A

CDK-interacting protein 1 , CDK-interaction protein 1 , DNA synthesis inhibitor , cyclin-dependent kinase inhibitor 1 , melanoma differentiation associated protein 6 , wild-type p53-activated fragment 1 , melanoma differentiation-associated protein , p21

1026 Homo sapiens
12575 Mus musculus
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