Browse our CDKN1A Proteins (CDKN1A)

Full name:
Cyclin-Dependent Kinase Inhibitor 1A Proteins (CDKN1A)
On are 3 Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) Proteins from 2 different suppliers available. Additionally we are shipping CDKN1A Kits (10) and CDKN1A Antibodies (4) and many more products for this protein. A total of 17 CDKN1A products are currently listed.
CAP20, CDKI, Cdkn1, CIP1, MDA-6, mda6, P21, p21Cip1, p21WAF, SDI1, Waf1
list all proteins Gene Name GeneID UniProt
CDKN1A 1026 P38936
Mouse CDKN1A CDKN1A 12575 P39689

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Human Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) interaction partners

  1. MiR (show MLXIP Proteins)-6734 inhibits the growth of colon cancer cells by up-regulating p21 gene expression.

  2. IFITM1 (show IFITM1 Proteins) suppression blocks proliferation and invasion of aromatase (show CYP19A1 Proteins) inhibitor-resistant breast cancer in vivo by JAK (show JAK3 Proteins)/STAT1 (show STAT1 Proteins)-mediated induction of p21.

  3. The results indicate that MF exposure can alter the G1 checkpoint response and that the p21 protein (show NRAS Proteins) may be involved in early responses to MF exposure.

  4. Disruption of CK1alpha (show CSNK1A1 Proteins) function in myeloma cells resulted in decreased Mdm2 (show MDM2 Proteins), increased p53 (show TP53 Proteins) and p21 and reduced expression of beta-catenin (show CTNNB1 Proteins) and AKT (show AKT1 Proteins).

  5. tumor-suppressor functions of SOCS1 (show SOCS1 Proteins) in the liver could be mediated, at least partly, via regulation of the expression, stability and subcellular distribution of p21 and its paradoxical oncogenic functions, namely, resistance to apoptosis and increased proliferation

  6. Here, the authors show that the CDK (show CDK4 Proteins) inhibitor p21 (CDKN1A) maintains the viability of DNA damage-induced senescent cells. Upon p21 knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM (show ATM Proteins)) and nuclear factor (NF)-kappaB (show NFKB1 Proteins) kinase, leading to decreased cell survival. NF-kappaB (show NFKB1 Proteins) activation induced TNF-alpha (show TNF Proteins) secretion and JNK (show MAPK8 Proteins) activation to mediate death of senescent cells in a...

  7. Data show that the resveratrol/docetaxel combination up regulated the expression of tumor supressor p53 (p53 (show TP53 Proteins)), and cell cycle inhibitors p21WAF1/CIP1 and p27KIP1 (show CDKN1B Proteins).

  8. these results demonstrated that the messenger RNA expression levels of p53 (show TP53 Proteins) and p21 may have a relationship with the changes in telomere length induced by omethoate and provided strong evidence for the mechanism of canceration induced by poison.

  9. Overexpression of these two microRNAs in A549 induced cell-cycle arrest and cell senescence, delayed cell proliferation and colony formation, and inhibited migration and invasion. In conclusion, microRNA-mediated RNAa depends on the cell context, and miR (show MLXIP Proteins)-1236 and miR (show MLXIP Proteins)-370 can inhibit non-small-cell lung carcinoma cell growth by upregulating p21 expression in vitro

  10. this study shows that allergen exposure modulates miR (show MLXIP Proteins)-132, and that repression of CDKN1A by allergen-induced miR (show MLXIP Proteins)-132 may contribute to shedding of bronchial epithelial cells

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) interaction partners

  1. FLT3 (show FLT3 Proteins)-ITD is capable of inhibiting FLT3 (show FLT3 Proteins)-ITD+ cell proliferation through the p21/Pbx1 (show PBX1 Proteins) axis

  2. These data reveal a novel role for p21/waf1 in the resolution of inflammation via its ability to control neutrophil apoptosis.

  3. the silencing of Cyclin-dependent kinase 5 (show CDK5 Proteins) preventing memory dysfunction

  4. Results show that p21 expression is regulated by OLA1 (show OLA1 Proteins) to promote cell proliferation and organogenesis.

  5. AS160 (show TBC1D4 Proteins) regulates glucose-independent eukaryotic cell proliferation through p21-dependent control of the cell cycle.

  6. telomerase activity and cardiomyocyte telomere length decrease sharply in wild-type mouse hearts after birth, resulting in cardiomyocytes with dysfunctional telomeres and anaphase bridges and positive for the cell-cycle arrest protein p21.

  7. Consistent with the latter, Arid1a reexpression in tumor cells led to increased p21 (Cdkn1a) expression and dramatic accumulation of cells in G2 phase of the cell cycle. These results also indicate a potential opportunity for therapeutic intervention in ARID1A-deficient human breast cancer subtypes that retain one intact copy of the gene and also maintain wild-type TRP53 (show TP53 Proteins) activity

  8. We discovered that FXR1P (show FXR1 Proteins)-deficient aNSCs have altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a, p21) as a direct target of FXR1P (show FXR1 Proteins).

  9. These results demonstrate that CQ and AQ increase the expression level of p21 and inhibit T cell proliferation and the development of IFN-gamma (show IFNG Proteins)-producing Th1 (show HAND1 Proteins) cells, thereby revealing beneficial roles in treating a wide range of chronic inflammatory diseases mediated by inflammatory T cells.

  10. increases the number of ALP (show CCL21A Proteins)-positive colonies after iPSC induction and decreases expression levels of Eomes (show EOMES Proteins) and p21 mRNAs. Based on these observations, we propose that the CCR4 (show CCR4 Proteins)-NOT deadenylase activity contributes to iPSC induction.

CDKN1A Protein Profile

Protein Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Alternative names and synonyms associated with CDKN1A

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A)
  • cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a)
  • CAP20 protein
  • CDKI protein
  • Cdkn1 protein
  • CIP1 protein
  • MDA-6 protein
  • mda6 protein
  • P21 protein
  • p21Cip1 protein
  • p21WAF protein
  • SDI1 protein
  • Waf1 protein

Protein level used designations for CDKN1A

CDK-interacting protein 1 , CDK-interaction protein 1 , DNA synthesis inhibitor , cyclin-dependent kinase inhibitor 1 , melanoma differentiation associated protein 6 , wild-type p53-activated fragment 1 , melanoma differentiation-associated protein , p21

1026 Homo sapiens
12575 Mus musculus
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