p21 Protein (AA 2-164) (GST tag)
Quick Overview for p21 Protein (AA 2-164) (GST tag) (ABIN5709265)
Target
See all p21 (CDKN1A) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 2-164
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Purification tag / Conjugate
- This p21 protein is labelled with GST tag.
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Sequence
- MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP
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Purification
- SDS-PAGE
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Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-164) protein (GST tag)
CDKN1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 2-164) protein (His-IF2DI Tag)CDKN1A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)CDKN1A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 425-719), (partial) protein (His-SUMO Tag)CDKN1A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.1-2 mg/mL
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Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
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Storage
- -80 °C,4 °C,-20 °C
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Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
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Alternative Name
- CDN1A
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Background
- May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assbly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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Molecular Weight
- 45.5 kDa
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UniProt
- P38936
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Pathways
- p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy
Target
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