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anti-Human FOXO3 Antibodies:
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Human FOXO3 Primary Antibody for IHC - ABIN966150
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for IHC - ABIN966151
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. in Oncogene 2005
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. in Urology 2012
Show all 2 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. in Genes & development 2012
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
Human Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN250244
Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. in Cell 1999
Human Polyclonal FOXO3 Primary Antibody for IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. in Disease models & mechanisms 2016
Dog (Canine) Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. in The Journal of cell biology 2002
by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Antibodies), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
NOTCH1 (show NOTCH1 Antibodies) inhibits activation of ATM (show ATM Antibodies) by impairing the formation of an ATM (show ATM Antibodies)-FOXO3a-KAT5 (show KAT5 Antibodies) complex.
FOXO3 is required to induce autophagy and thereby reduce elevated reactive oxygen species levels.
A total of 41 differentially expressed genes, such as SOCS3 (show SOCS3 Antibodies), VAPA (show VAPA Antibodies), and COL5A2 (show COL5A2 Antibodies), are speculated to have roles in the pathogenesis of acute myocardial infarction; 2 transcription factors FOXO3 and MYBL2 (show MYBL2 Antibodies), and 2 miRNAs hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-21-5p and hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-30c-5p may be involved in the regulation of the expression of these differentially expressed genes.
Downregulation of PKC (show PRRT2 Antibodies) induces senescence through the AKT (show AKT1 Antibodies)-FoxO3a-ROS (show ROS1 Antibodies)-p53 (show TP53 Antibodies)-p21(Cip1/WAF1 (show CDKN1A Antibodies)) pathway in HCT116 and HEK293 cells.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
TLR4 (show TLR4 Antibodies) and C5aR (show C5AR1 Antibodies) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Antibodies), PI3Kbeta, SGK1 (show SGK1 Antibodies), and FOXO transcription factors.
FoxO3a is an early stress response protein to glucose toxicity in diabetic conditions.
In cigarette smoke extract stimulated bronchial epithelial cells, carbocysteine increased cell proliferation, and SIRT1 (show SIRT1 Antibodies) and FoxO3 nuclear expression, and reduced beta galactosidase (show GLB1 Antibodies) and survivin (show BIRC5 Antibodies) expression.
geminin (show GMNN Antibodies) selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3 (show HDAC3 Antibodies), thereby specifically facilitating FoxO3 deacetylation.
Data suggest that forkhead box O3A protein (FoxO3a) might be a prognostic biomarker or a potential therapeutic target in glioblastoma.
MiR (show MLXIP Antibodies)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (show EOMES Antibodies) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (show HAND1 Antibodies) cell differentiation.
these results show that Cdk5 (show CDK5 Antibodies)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (show APP Antibodies) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (show IL6 Antibodies) in the blood.
results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible
Foxo1 (show FOXO1 Antibodies), Foxo3a, and Foxo4 (show FOXO4 Antibodies) in chondrocytes regulate endochondral bone formation.
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (show SIRT3 Antibodies) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha (show PPARGC1A Antibodies) and SOD2 (show SOD2 Antibodies).
These results indicate that myostatin (show MSTN Antibodies) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Antibodies) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN (show PTEN Antibodies), FOXO3A and PKB (show AKT1 Antibodies) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
NO/protein kinase (show CDK7 Antibodies) G (PKG (show PRKG1 Antibodies))-dependent downregulation of PGC-1 alpha (show PPARGC1A Antibodies) and the ROS (show ROS1 Antibodies) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Antibodies) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (show ROS1 Antibodies)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like