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anti-Human FOXO3 Antibodies:
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Human FOXO3 Primary Antibody for IHC - ABIN966150
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for IHC - ABIN966151
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. in Oncogene 2005
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. in Urology 2012
Show all 2 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN250244
Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. in Cell 1999
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. in Genes & development 2012
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
Human Polyclonal FOXO3 Primary Antibody for IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. in Disease models & mechanisms 2016
Dog (Canine) Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. in The Journal of cell biology 2002
Knockdown of MIEF2 reduces DOX-induced mitochondrial fission and apoptosis in cardiomyocytes and in vivo. Also, knockdown of MIEF2 protects heart from DOX-induced cardiotoxicity. Our study identifies a novel pathway composed of Foxo3a and MIEF2 that mediates DOX cardiotoxicity.
data show that the GSK3B (show GSK3b Antibodies)-FOXO3 pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (show IGF1R Antibodies) after partial hepatectomy.
Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients.
Diabetic Glc also promoted beta-catenin (show CTNNB1 Antibodies) nuclear localization and the formation of a complex with FOXO3a that localized to the promoters of Sod2 (show SOD2 Antibodies), p21(cip1 (show CDKN1A Antibodies)), and potentially p27(kip1 (show CDKN1B Antibodies))
in FOXO3-death-resistant cells no point mutations in the TP53 (show TP53 Antibodies)-DBD were found-in these cells FOXO3-TP53 (show TP53 Antibodies) complexes are formed and FOXO3-binding to the BIM (show BCL2L11 Antibodies)-promoter, but not the induction of the detoxifying protein SESN3 (show SESN3 Antibodies), were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (show ARHGEF16 Antibodies) cells
Taken together, these findings showed that TRIP6 (show TRIP6 Antibodies) plays an important role in promoting HCC (show FAM126A Antibodies) cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC (show FAM126A Antibodies).
NOTCH1 (show NOTCH1 Antibodies) inhibits activation of ATM (show ATM Antibodies) by impairing the formation of an ATM (show ATM Antibodies)-FOXO3a-KAT5 (show KAT5 Antibodies) complex.
FOXO3 is required to induce autophagy and thereby reduce elevated reactive oxygen species levels.
A total of 41 differentially expressed genes, such as SOCS3 (show SOCS3 Antibodies), VAPA (show VAPA Antibodies), and COL5A2 (show COL5A2 Antibodies), are speculated to have roles in the pathogenesis of acute myocardial infarction; 2 transcription factors FOXO3 and MYBL2 (show MYBL2 Antibodies), and 2 miRNAs hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-21-5p and hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-30c-5p may be involved in the regulation of the expression of these differentially expressed genes.
Downregulation of PKC (show PRRT2 Antibodies) induces senescence through the AKT (show AKT1 Antibodies)-FoxO3a-ROS (show ROS1 Antibodies)-p53 (show TP53 Antibodies)-p21(Cip1/WAF1 (show CDKN1A Antibodies)) pathway in HCT116 and HEK293 cells.
These results indicate that myostatin (show MSTN Antibodies) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Antibodies) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN (show PTEN Antibodies), FOXO3A and PKB (show AKT1 Antibodies) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Antibodies), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
BIM (show BCL2L11 Antibodies)-dependent death during CD8 (show CD8A Antibodies)(+) T-cell deletion is FOXO3 independent.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (show MUL1 Antibodies) FBXO32/atrogin-1 (show FBXO32 Antibodies) and its transcription factor FOXO3A.
MiR (show MLXIP Antibodies)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (show EOMES Antibodies) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (show HAND1 Antibodies) cell differentiation.
these results show that Cdk5 (show CDK5 Antibodies)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (show APP Antibodies) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (show IL6 Antibodies) in the blood.
NO/protein kinase (show CDK7 Antibodies) G (PKG (show PRKG1 Antibodies))-dependent downregulation of PGC-1 alpha (show PPARGC1A Antibodies) and the ROS (show ROS1 Antibodies) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Antibodies) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (show ROS1 Antibodies)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like