Browse our anti-Retinoblastoma 1 (RB1) Antibodies

On www.antibodies-online.com are 628 Retinoblastoma 1 (RB1) Antibodies from 30 different suppliers available. Additionally we are shipping Retinoblastoma 1 Kits (40) and Retinoblastoma 1 Proteins (16) and many more products for this protein. A total of 754 Retinoblastoma 1 products are currently listed.
Synonyms:
OSRC, P105-RB, PP110, pRb, Rb, Rb-1, RB1, RB11, zgc:154147
list all antibodies Gene Name GeneID UniProt
RB1 5925 P06400
RB1 19645 P13405
RB1 24708 P33568

Most Popular Reactivities for anti-Retinoblastoma 1 (RB1) Antibodies

anti-Human Retinoblastoma 1 Antibodies:

anti-Mouse (Murine) Retinoblastoma 1 Antibodies:

anti-Rat (Rattus) Retinoblastoma 1 Antibodies:

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More Antibodies against Retinoblastoma 1 Interaction Partners

Human Retinoblastoma 1 (RB1) interaction partners

  1. RB1 deficiency promotes cancer cell proliferation in part by enhancing mitochondrial function and identify tigecycline as a clinically approved drug for RB1-deficient triple negative breast cancer.

  2. this paper shows that patients with estrogen receptor (show ESR1 Antibodies) positive breast cancer expressing high Rb loss-of-function have significantly worse recurrence free survival compared to those with low Rb loss-of-function

  3. Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 (show CCNE2 Antibodies) Transcription, and Proliferation of MCF-7 Breast Cancer Cells

  4. TYROBP (show TYROBP Antibodies) influences a batch of genes that are related to Alzheimer's disease; ZNF329 (show ZNF329 Antibodies) and RB1 significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.

  5. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (show E2F1 Antibodies) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (show CDK4 Antibodies) inhibitors in breast cancer for the development of more effective combination therapies.

  6. Here, we introduce a transcriptional signature to specifically track CDK2 (show CDK2 Antibodies) activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 Antibodies)-RB-E2F (show E2F1 Antibodies) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (show CDK2 Antibodies) activity during cell cycle progression

  7. The N-Terminal phosphorylation of RB by p38 (show CRK Antibodies) bypasses its inactivation by cyclin (show PCNA Antibodies)-dependent kinases and prevents proliferation in cancer cells.

  8. Suggest frequent Rb1 deficiency as a possible driver molecular event in superficial acral fibromyxoma.

  9. The expression of Rb and MeCP2 (show MECP2 Antibodies) in patients with B-cell non-Hodgkin's lymphoma (B-NHL (show RTEL1 Antibodies)) showed that positive staining for MeCP2 (show MECP2 Antibodies) or Rb was significantly lower in B-NHL (show RTEL1 Antibodies) tumor tissues, and these changes were significantly and negatively correlated with the grade of B-NHL (show RTEL1 Antibodies).

  10. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 (show CDK4 Antibodies) inhibitors releases Rb-mediated mTORC2 (show CRTC2 Antibodies) suppression. This, in turn, leads to elevated Akt (show AKT1 Antibodies) activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt (show AKT1 Antibodies) inhibitors.

Mouse (Murine) Retinoblastoma 1 (RB1) interaction partners

  1. Combined deletion of Vhl (show VHL Antibodies), Trp53 (show TP53 Antibodies) and Rb1 specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (show MOK Antibodies).

  2. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 (show E2F1 Antibodies) to recruit EZH2 (show EZH2 Antibodies) to diverse repeat sequences.

  3. The N-Terminal phosphorylation of RB by p38 (show CRK Antibodies) bypasses its inactivation by cyclin (show PCNA Antibodies)-dependent kinases and prevents proliferation in cancer cells.

  4. SUMO1 (show SUMO1 Antibodies) conjugation of RB and Lamin A/C (show LMNA Antibodies) is modulated by the SUMO protease SENP1 (show SENP1 Antibodies) and that sumoylation of both proteins is required for their interaction.

  5. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 (show CDK4 Antibodies) inhibitors releases Rb-mediated mTORC2 (show CRTC2 Antibodies) suppression. This, in turn, leads to elevated Akt (show AKT1 Antibodies) activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt (show AKT1 Antibodies) inhibitors.

  6. The data presented here support a hypothesis in which RB1 and TP53 (show TP53 Antibodies) loss in prostate cancer derepresses Ezh2 (show EZH2 Antibodies) and Sox2 (show SOX2 Antibodies) factors, creating a stem cell-like epigenetic environment permissive for lineage plasticity

  7. systems-level control of cell cycle arrest by pRB (show PGR Antibodies)-E2F (show E2F1 Antibodies) and p27 (show CDKN1B Antibodies)-CDK (show CDK4 Antibodies) regulation, is reported.

  8. RB is necessary for the recruitment of the BRG1 (show SMARCA4 Antibodies) ATPase (show DNAH8 Antibodies) to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination

  9. Findings implicate Rb1 in the regulation of the THO ribonucleoprotein complex.

  10. contribution of these precursors to the Rb(+/-) adipose phenotype is driven, at least in part, by interaction with BMP7 (show BMP7 Antibodies) pathway

Zebrafish Retinoblastoma 1 (RB1) interaction partners

  1. Our results indicate that Rb-Raf-1 (show RAF1 Antibodies) interaction plays an important role in spontaneous hair cell regeneration in zebrafish

  2. our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.

  3. Zebrafish usp39 (show USP37 Antibodies) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (show E2F4 Antibodies) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators

Retinoblastoma 1 (RB1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Alternative names and synonyms associated with Retinoblastoma 1 (RB1)

  • retinoblastoma 1 (including osteosarcoma) (RB1) antibody
  • retinoblastoma 1 (RB1) antibody
  • Retinoblastoma-associated protein (rb) antibody
  • retinoblastoma 1 (Rb1) antibody
  • retinoblastoma 1 (rb1) antibody
  • OSRC antibody
  • P105-RB antibody
  • PP110 antibody
  • pRb antibody
  • Rb antibody
  • Rb-1 antibody
  • RB1 antibody
  • RB11 antibody
  • zgc:154147 antibody

Protein level used designations for anti-Retinoblastoma 1 (RB1) Antibodies

retinoblastoma 1 (including osteosarcoma) , retinoblastoma protein 1 , retinoblastoma-associated protein , Retinoblastoma-associated protein , retinoblastoma 1 , retinoblastoma-associated protein-like , retinoblastoma suspectibility protein , pp105 , retinoblastoma protein , Retinoblastoma 1 (including osteosarcoma) , pRb , rb , p104 , spc , retinoblastoma, susceptibility

GENE ID SPECIES
449604 Pan troglodytes
452715 Pan troglodytes
704871 Macaca mulatta
100217687 Taeniopygia guttata
100380330 Salmo salar
100397928 Callithrix jacchus
5925 Homo sapiens
19645 Mus musculus
476915 Canis lupus familiaris
100057080 Equus caballus
24708 Rattus norvegicus
386582 Gallus gallus
777733 Danio rerio
534712 Bos taurus
100716297 Cavia porcellus
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