Retinoblastoma 1 antibody (pSer612)

Catalog No. ABIN389643

Cited in 1 publication. The Rabbit Polyclonal anti-Retinoblastoma 1 antibody (Clone RB7659) (ABIN389643) specifically detects Retinoblastoma 1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Retinoblastoma 1 antibody (pSer612) (ABIN389643)

Target: Retinoblastoma 1 (RB1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB7659

Product Details anti-Retinoblastoma 1 Antibody

Binding Specificity: pSer612

Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S612 of human RB

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This RB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S612 of human RB.

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000, IHC (p) = 1:50-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.38 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Retinoblastoma 1 antibody (ABIN389643)

Rizzolio, Lucchetti, Caligiuri, Marchesi, Caputo, Klein-Szanto, Bagella, Castronovo, Giordano: "Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1." in: Cell death and differentiation, Vol. 19, Issue 7, pp. 1152-61, (2012) (PubMed).

Target Details for Retinoblastoma 1

Target: Retinoblastoma 1 (RB1)

Alternative Name: RB

Background: Synonyms: Retinoblastoma-associated protein, PP110, P105-RB, RB, RB1,

Molecular Weight: 106159 DA

Gene ID: 5925

UniProt: P06400

Pathways: Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy