Browse our anti-Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) Antibodies

Full name:
anti-Glutamate-Cysteine Ligase, Catalytic Subunit Antibodies (GCLC)
On www.antibodies-online.com are 134 Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) Antibodies from 22 different suppliers available. Additionally we are shipping Glutamate-Cysteine Ligase, Catalytic Subunit Kits (27) and Glutamate-Cysteine Ligase, Catalytic Subunit Proteins (12) and many more products for this protein. A total of 180 Glutamate-Cysteine Ligase, Catalytic Subunit products are currently listed.
Synonyms:
2259, cb1049, CG2259, D9Wsu168e, DDBDRAFT_0186120, DDBDRAFT_0231403, DDB_0186120, DDB_0231403, Dmel\\CG2259, DmGCLC, DmGCS, DmGCSh, fe36e11, GCL, GCLc, GCS, Gcsh, Ggcs-hs, GLCL, GLCL-H, Glclc, MGC146287, wu:fe36e11

Most Popular Reactivities for anti-Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) Antibodies

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All available anti-Glutamate-Cysteine Ligase, Catalytic Subunit Antibodies

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Top referenced anti-Glutamate-Cysteine Ligase, Catalytic Subunit Antibodies

  1. Human Monoclonal GCLC Primary Antibody for IF, ELISA - ABIN561050 : Hardwick, Fisher, Canet, Lake, Cherrington: Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease. in Drug metabolism and disposition: the biological fate of chemicals 2010 (PubMed)
    Show all 6 references for 561050

  2. Human Polyclonal GCLC Primary Antibody for EIA, FACS - ABIN952477 : Man, Baum, Fu, Chan, Lam, Hui, Leung, Wong: Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2010 (PubMed)
    Show all 3 references for 952477

  3. Cow (Bovine) Polyclonal GCLC Primary Antibody for IHC, WB - ABIN2785780 : Bardag-Gorce, Oliva, Lin, Li, French, French: Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. in Experimental and molecular pathology 2011 (PubMed)
    Show all 2 references for 2785780

  4. Cow (Bovine) Polyclonal GCLC Primary Antibody for IP, WB - ABIN4313738 : Theodoratos, Blackburn, Cappello, Tummala, Dahlstrom, Board: Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase. in Biochemical pharmacology 2011 (PubMed)

  5. Cow (Bovine) Polyclonal GCLC Primary Antibody for IHC, WB - ABIN2774078 : Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. in International archives of occupational and environmental health 2008 (PubMed)

More Antibodies against Glutamate-Cysteine Ligase, Catalytic Subunit Interaction Partners

Fruit Fly (Drosophila melanogaster) Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) interaction partners

  1. Microarray analysis revealed that glutamate (show GRIN2A Antibodies) cysteine ligasec overexpression and thus enhanced glutathione production has a broad impact on gene expression that largely affects different processes in young and old flies.

  2. investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels

  3. Neuronal overexpression of GCLc in a long-lived background extended mean and maximum life spans up to 50%, without affecting the rate of oxygen consumption by the flies

  4. The reversibility of the dephosphorylation-dependent activation was indicated by the time-dependent inactivation of the in vitro activated Drosophila GCL, by preincubation with MgATP.

  5. that the longevity effects of GCLc are dependent on dosage and that there are specific tissues (mushroom bodies, motor neurons, and transverse muscle cells) particularly sensitive to the benefits of GCLc overexpression.

  6. GSH biosynthesis in the nucleus is associated with migration of only the GCLc subunit from the cytoplasm into the nucleus, and this migration requires the presence of an intact nuclear localization signal

Human Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) interaction partners

  1. GCLC polymorphisms correlated with brain GSH and Glu (show DCTN1 Antibodies) levels in psychosis.

  2. NQO1 (show NQO1 Antibodies) and GCLC were both functionally sufficient to autonomously confer a tamoxifen-resistant metabolic phenotype, characterized by i) increased mitochondrial biogenesis, ii) increased ATP production and iii) reduced glutathione levels.

  3. (i) melatonin counteracted UVR-induced alterations in the ATP synthesis and reduced free radical formation; (ii) melatonin induced the translocation of Nrf2 (show GABPA Antibodies) transcription factor from the cytosol into the nucleus resulting in, (iii) melatonin enhanced gene expression of phase-2 antioxidative enzymes including gamma-glutamylcysteine synthetase (gamma-GCS), heme oxygenase-1 (HO-1 (show HMOX1 Antibodies)), and NADPH (show NQO1 Antibodies): quinone dehydrogenase-1 (NQO1 (show NQO1 Antibodies)...

  4. Glutaminolysis is activated in ES2 (show DGCR14 Antibodies) and OVCAR3, though ES2 (show DGCR14 Antibodies) exclusively synthesizes amino acids and GSH. ES2 (show DGCR14 Antibodies) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (show DGCR14 Antibodies) to carboplatin. HNF1beta (show HNF1B Antibodies) regulates the expression of GCLC, but not GCLM (show GCLM Antibodies), and consequently GSH production in ES2 (show DGCR14 Antibodies)

  5. miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.

  6. Data suggest expression of hepatocyte GCLC and GCLM (show GCLM Antibodies) can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC and GCLM (show GCLM Antibodies) expression.

  7. Cigarette smoke-induced hypermethylation of the GCLC promoter is related to the initiation and progression of COPD (show ARCN1 Antibodies).

  8. GCLC and GSS (show GSS Antibodies) were expressed at higher levels in colon cancer tissue, as compared with normal mucosa.

  9. The Kaplan-Meier analysis shows that rs3736729 on GCLC presents a significant association with disease-free survival and overall survival.

  10. H2S upregulates GCLC and GSH and inhibits IL-1beta (show IL1B Antibodies) levels, which may be what mediates the beneficial effects of H2S-rich compounds in mitigating the pathogenesis of metabolic syndrome and atherosclerosis

Mouse (Murine) Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) interaction partners

  1. Data show that the catalytic subunit of glutamate cysteine ligase (Gclc)-derived glutathione buffers reactive oxygen species (ROS (show ROS1 Antibodies)), and regulates metabolic reprogramming.

  2. To study the biological effects of low GSH levels, we disrupted its synthesis both at birth by breeding a Gclc loxP mouse with a thy1 (show THY1 Antibodies)-cre mouse and at a later age by breeding with a CaMKII (show CAMK2G Antibodies)-ERT2 (show MAPK3 Antibodies)-Cre (FIGSKO mouse). FIGSKO mice also develop cognitive abnormalities, i.e. learning impairment and nesting behaviors based on passive avoidance, T-Maze, and nesting behavior tests

  3. A floxed Gclc mouse was generated and crossed with a transgenic mouse expressing Cre in the lens to generate the Lens Glutathione Synthesis Knockout mouse in which de novo GSH synthesis was completely abolished in the lens.

  4. Clinically relevant levels of TGF-beta1 (show TGFB1 Antibodies) suppresses GCLC and GCLM (show GCLM Antibodies) expression in mouse lung.

  5. Data show for the first time that GCLC may serve a dual role, as a surrogate marker for cellular redox state as well as malignant potential of melanoma cells.

  6. The impacts of four clinical missense mutations on GCLC enzymatic function in vivo and in vitro, was evaluated.

  7. tBHQ has beneficial effects on reducing hyperglycemia-induced kidney injury, which is associated with the enhanced expression of Nrf2 (show NFE2L2 Antibodies), and its downstream antioxidant HO-1 (show HMOX1 Antibodies) and gamma-GCS (show UGCG Antibodies) in the glomeruli of diabetic mice

  8. In first days of life luminescence measured was in all mice with distinct strain differences indicating NF-kappaB (show NFKB1 Antibodies), superoxide dismutase (show SOD1 Antibodies), gamma-glutamylcysteine synthetase, and antioxidant responsive element activity.

  9. Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C. 6.3.2.2) and glutathione synthase (show GSS Antibodies) (GS) (E.C. 6.3.2.3)

  10. activation of GSK-3beta (show GSK3b Antibodies) is a key mediator of the initial phase of acetaminophen-induced liver injury through modulating GCL and Mcl-1 (show MCL1 Antibodies) degradation, as well as JNK (show MAPK8 Antibodies) activation in liver

Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) Antigen Profile

Antigen Summary

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.

Alternative names and synonyms associated with Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC)

  • glutamate-cysteine ligase, catalytic subunit (GCLC) antibody
  • glutamate-cysteine ligase, catalytic subunit (gclc) antibody
  • Glutamate-cysteine ligase catalytic subunit (Gclc) antibody
  • gamma glutamylcysteine synthetase (LbGCS) antibody
  • gamma glutamylcysteine synthetase (gcsA) antibody
  • glutamate-cysteine ligase, catalytic subunit (LOC100049719) antibody
  • gamma-glutamylcysteine synthetase (GSH1) antibody
  • glutamate-cysteine ligase, catalytic subunit (Gclc) antibody
  • 2259 antibody
  • cb1049 antibody
  • CG2259 antibody
  • D9Wsu168e antibody
  • DDBDRAFT_0186120 antibody
  • DDBDRAFT_0231403 antibody
  • DDB_0186120 antibody
  • DDB_0231403 antibody
  • Dmel\\CG2259 antibody
  • DmGCLC antibody
  • DmGCS antibody
  • DmGCSh antibody
  • fe36e11 antibody
  • GCL antibody
  • GCLc antibody
  • GCS antibody
  • Gcsh antibody
  • Ggcs-hs antibody
  • GLCL antibody
  • GLCL-H antibody
  • Glclc antibody
  • MGC146287 antibody
  • wu:fe36e11 antibody

Protein level used designations for GCLC

glutamate--cysteine ligase catalytic subunit , glutamate-cysteine ligase, catalytic subunit , CG2259-PA , CG2259-PB , Gclc-PA , Gclc-PB , gamma-Glutamylcysteine synthetase , gamma-Glutamylcysteine synthetase catalytic subunit , gamma-glutamylcysteine ligase , glutamate cysteine ligase , glutamate-cysteine ligase , gamma glutamylcysteine synthetase , gamma-ECS , glutamate--cysteine ligase, chloroplastic , GCS heavy chain , gamma-glutamylcysteine synthetase , gamma GCS-HS , gamma-glutamylcysteine synthetase heavy subunit , Glutamylcysteine gamma synthetase light chain , glutamate-cysteine ligase catalytic subunit

GENE ID SPECIES
710508 Macaca mulatta
742732 Pan troglodytes
780264 Xenopus (Silurana) tropicalis
53581 Drosophila melanogaster
6073019 Laccaria bicolor S238N-H82
8624704 Dictyostelium discoideum AX4
100049719 Xenopus laevis
100137615 Xenopus laevis
543536 Solanum lycopersicum
2729 Homo sapiens
14629 Mus musculus
25283 Rattus norvegicus
326857 Danio rerio
609822 Canis lupus familiaris
512468 Bos taurus
421894 Gallus gallus
100726181 Cavia porcellus
100522018 Sus scrofa
100342383 Oryctolagus cuniculus
101114822 Ovis aries
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