Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

GCLC Products

(Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured GCLC Categories

GCLC Antibodies

High quality antibodies with extensive validation data.

GCLC ELISA Kits

Reliable ELISA kits for a wide range of species.

GCLC Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GCLC Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (6)
  • (7)
Cat. No. ABIN561050
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, FACS, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN655884
Quantity 400 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC
Validations
  • (1)
  • (5)
Cat. No. ABIN2774078
Quantity 100 μL
Datasheet Datasheet

Recommended GCLC ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956167
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967068
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956168
Quantity 96 tests
Datasheet Datasheet

Recommended GCLC Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123113
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354922
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354924
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our GCLC products

Ge, Chen, Yao, Zhou, Huang, Cai, Hei: "Overexpression of Brg1 Alleviates Hepatic Ischemia/Reperfusion-Induced Acute Lung Injury through Antioxidative Stress Effects." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 8787392, (2018) (PubMed).

Khaliq, Jing, Ke, Ke-Li, Peng-Peng, Cui, Wei-Wei, Zhixin, Hua-Zhen, Hui, Ju-Ming, Ke-Mei: "Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks." in: Biological trace element research, Vol. 186, Issue 1, pp. 226-237, (2018) (PubMed).

Petersen, Saba, Sayin, Papagiannakopoulos, Schmidt, Merrill, Orlicky, Shearn: "Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice." in: PLoS ONE, Vol. 13, Issue 5, pp. e0198139, (2018) (PubMed).

Zou, Wang, Peng, Wei: "Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 5987183, (2017) (PubMed).

Li, Sun, Liu, Zhao, Shao: "Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 102, pp. 93-101, (2017) (PubMed).

Ni, Wang, Qiu, Pang, Song, Guo: "Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling." in: International journal of clinical and experimental pathology, Vol. 8, Issue 7, pp. 7752-61, (2016) (PubMed).

Jin, Li, Zhang, Wu, Feng, Zhang, Shen: "Electroacupuncture alleviates cerebral ischemia and reperfusion injury via modulation of the ERK1/2 signaling pathway." in: Neural regeneration research, Vol. 11, Issue 7, pp. 1090-8, (2016) (PubMed).

Yang, Yao, Chen, Sun, Li, Ma, Duan, Li, Xiang, Han, Duan: "Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake." in: The Journal of biological chemistry, Vol. 290, Issue 36, pp. 21788-99, (2015) (PubMed).

Sugiyama, Ebinuma, Nakamoto, Sakasegawa, Murakami, Chu, Usui, Ishibashi, Wakayama, Taniki, Murata, Saito, Fukasawa, Saito, Yamagishi, Wakita, Takaku, Hibi, Saito, Kanai: "Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus." in: PLoS ONE, Vol. 9, Issue 4, pp. e94460, (2014) (PubMed).

Venè, Cardinali, Arena, Ferrari, Benelli, Minghelli, Poggi, Noonan, Albini, Tosetti: "Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 9, pp. 710-22, (2014) (PubMed).

Synonyms and alternative names related to GCLC

glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase, catalytic subunit (gclc), Glutamate-cysteine ligase catalytic subunit (Gclc), gamma glutamylcysteine synthetase (LbGCS), gamma glutamylcysteine synthetase (gcsA), glutamate-cysteine ligase, catalytic subunit L homeolog (gclc.L), glutamate-cysteine ligase, catalytic subunit S homeolog (gclc.S), gamma-glutamylcysteine synthetase (GSH1), glutamate-cysteine ligase, catalytic subunit (Gclc), glutamate-cysteine ligase catalytic subunit (Gclc), 2259, cb1049, CG2259, D9Wsu168e, DDBDRAFT_0186120, DDBDRAFT_0231403, DDB_0186120, DDB_0231403, Dmel\\CG2259, DmGCLC, DmGCS, DmGCSh, fe36e11, GCL, GCLC, gclc, GCLc, Gcs, GCS, GCSh, Gcsh, Ggcs-hs, GLCL, GLCL-H, GLCLC, Glclc, MGC146287, wu:fe36e11

Protein level used designations for GCLC

  • glutamate--cysteine ligase catalytic subunit
  • glutamate-cysteine ligase, catalytic subunit
  • CG2259-PA
  • CG2259-PB
  • Gclc-PA
  • Gclc-PB
  • gamma-Glutamylcysteine synthetase
  • gamma-Glutamylcysteine synthetase catalytic subunit
  • gamma-glutamylcysteine ligase
  • glutamate cysteine ligase
  • glutamate-cysteine ligase
  • gamma glutamylcysteine synthetase
  • gamma-ECS
  • glutamate--cysteine ligase, chloroplastic
  • GCS heavy chain
  • gamma-glutamylcysteine synthetase
  • gamma GCS-HS
  • gamma-glutamylcysteine synthetase heavy subunit
  • Glutamylcysteine gamma synthetase light chain
  • glutamate-cysteine ligase catalytic subunit
You are here:
Support